Skip to main content

Advertisement

SpringerLink
Log in

Tubulointerstitial nephritis and uveitis in monozygotic twin boys

  • Brief Report
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

We describe monozygotic male twins who developed tubulointerstitial nephritis and uveitis (TINU) almost 2 years apart. They presented with non-specific symptoms and were noted to have glycosuria and renal impairment. Both children have uveitis. One had biopsy-proven interstitial nephritis and the other had biochemical evidence of transient tubular dysfunction. While the renal parameters improved, they are still under treatment for uveitis. The occurrence of TINU in identical twins at an interval of just under 2 years supports a strong genetic element in the aetiology of this syndrome. We believe this is the first report of male twins with TINU.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Dobrin RS, Vernier RL, Fish AJ (1975) Acute interstitial nephritis and renal failure with bone marrow lymph node granulomas and anterior uveitis. A new syndrome. Am J Med 59:325–333

    CAS  PubMed  Google Scholar 

  2. Mandeville JT, Levinson RD, Holland (2001) The tubulointerstitial nephritis and uveitis syndrome. Surv Ophthalmol 46:195–208

    Article  PubMed  Google Scholar 

  3. Vohra S, Eddy A, Levin AV, Taylor G (1999) Tubulointerstitial nephritis and uveitis in children and adolescents. Pediatr Nephrol 13:426–431

    CAS  PubMed  Google Scholar 

  4. Ellis D, Fried WA, Yunis EJ, Blau EB (1981) Acute interstitial nephritis in children: a report of 13 cases and a review of the literature. Pediatrics 67:862–870

    CAS  PubMed  Google Scholar 

  5. Litwin M, Michalkiewicz J, Jarmuzek W, Wozniewicz B, Grenada R, Iwanicka K, Madalinski K (2002) Tubulointerstitial nephritis with uveitis: clinicopathological and immunological study. Pediatr Nephrol 17:683–688

    Article  PubMed  Google Scholar 

  6. Gianviti A, Greco M, Barsotti P, Rizzoni G (1994) Acute tubulointerstitial nephritis occurring with 1-year lapse in identical twins. Pediatr Nephrol 8:427–430

    CAS  PubMed  Google Scholar 

  7. Sanchez RJ, Gonzalez RI, Castillo PMJ, Rocha CJL (1995) Posterior uveitis associated with acute tubulointerstitial nephritis with favorable response to cyclosporin. Pathogenic implications. Med Clin (Barc) 104:118

    Google Scholar 

  8. Iitsuka T, Yamagucchi N, Kobayashi M, Nakamura H, Usuki J, Koyama H (1993) HLA tissue types in patients with acute tubulointerstitial nephritis accompanying uveitis. Nippon Jinza Gakkai Shi 35:723–731

    CAS  Google Scholar 

  9. Gafter U, Kalechman Y, Zevin D, Korzets A, Livni E, Klein T, Sredni B, Levi J (1993) Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. Nephrol Dial Transplant 8:821–826

    CAS  PubMed  Google Scholar 

  10. Levinson RD, Park MS, Rikkers SM, Reed EF, Smith JR, Martin TM, Rosenbaum JT, Foster CS, Sherman MD, Holland GN (2003) Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Invest Ophthalmol Vis Sci 44:653–657

    Article  PubMed  Google Scholar 

  11. Morino M, Inami K, Kobayashi T, Yanagisawa K, Maeda K (1991) Acute interstitial nephritis in two siblings and concurrent uveitis in one. Acta Pediatr Jpn 33:93–98

    CAS  Google Scholar 

  12. Tanaka H, Suzuki K, Nakahata T, Tateyama T, Waga S, Ito E (2001) Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. Pediatr Nephrol 16:885–887

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatric Nephrology, Southampton General Hospital, Tremona Road, Southampton, SO 16 6YD, UK

    Lucy Howarth, Rodney D. Gilbert & Pankaj V. Deshpande

  2. Department of Cellular Pathology, Southampton General Hospital, Tremona Road, Southampton, SO 16 6YD, UK

    Paul Bass

  3. Department of Paediatric Nephrology, Southampton General Hospital, G level, Tremona Road, Southampton, SO 16 6YD, UK

    Pankaj V. Deshpande

Authors
  1. Lucy Howarth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rodney D. Gilbert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paul Bass
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pankaj V. Deshpande
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pankaj V. Deshpande.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Howarth, L., Gilbert, R.D., Bass, P. et al. Tubulointerstitial nephritis and uveitis in monozygotic twin boys. Pediatr Nephrol 19, 917–919 (2004). https://doi.org/10.1007/s00467-004-1518-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-004-1518-9

Keywords

Search

Navigation