Abstract
Long-lasting recovery of renal function of the native kidneys after prolonged renal replacement therapy is rare. An 8-year-old girl and a 3-year-old boy had suffered from acute atypical and diarrhea-associated hemolytic uremic syndrome (HUS), respectively, with subsequent apparent end-stage renal failure. Both recovered renal function after long-lasting anuria and dialysis of 8 and 16 months, respectively. After prolonged follow-up, i.e., 7 and 5 years after cessation of dialysis, they attained normal or slightly reduced renal function (plasma creatinine 84 and 90 µmol/l, respectively). In addition, growth and cognitive development were normal. We conclude that caution is appropriate before offering early renal transplantation to pediatric patients with presumed end-stage kidney disease secondary to HUS.
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Brunner, K., Bianchetti, M.G. & Neuhaus, T.J. Recovery of renal function after long-term dialysis in hemolytic uremic syndrome. Pediatr Nephrol 19, 229–231 (2004). https://doi.org/10.1007/s00467-003-1337-4
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DOI: https://doi.org/10.1007/s00467-003-1337-4