Abstract
Currently, there are no data available on long-term effects of angiotensin-converting enzyme inhibitors (ACE-I) on graft function in children after renal transplantation. We therefore analyzed all children who were transplanted at our institution between 1989 and 1998 and followed for at least 2 years. Those treated with ACE-I, mainly because of failure of other antihypertensive medications, were compared to those without ACE-I. The ACE-I-treated children (n=19) showed significantly better blood pressure control during the 1st year of follow-up (p<0.05). In children with chronic allograft dysfunction (n=8), treatment with ACE-I stabilized graft function, with improvement in creatinine clearance in 50% (p<0.01). Serum potassium and hemoglobin levels remained stable. One patient discontinued ACE-I because of renal artery stenosis. Taken together, ACE-I were effective and safe in the treatment of hypertension in children following renal transplantation. Children with chronic allograft dysfunction experienced a stabilizing effect on graft function.
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This study was supported by the Medizinisch-Wissenschaftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien.
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Arbeiter, K., Pichler, A., Stemberger, R. et al. ACE inhibition in the treatment of children after renal transplantation. Pediatr Nephrol 19, 222–226 (2004). https://doi.org/10.1007/s00467-003-1317-8
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DOI: https://doi.org/10.1007/s00467-003-1317-8