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Urinary excretion of endothelin-1 in children with absorptive idiopathic hypercalciuria

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Abstract

Urinary excretion of endothelin-1 (ET-1) and plasma ET-1 were measured in 21 children with absorptive idiopathic hypercalciuria (AIH) and 22 controls. The absorptive type of idiopathic hypercalciuria was determined by a calcium loading test. Daily urinary excretion of ET-1 and urinary ET-1/creatinine ratio were significantly increased (P=0.005 and P=0.007, respectively) in patients with AIH (9,274±6,444 pg/24 h and 14.04±9.52 pg/mg, respectively) compared with controls (4,699±2,120 pg/24 h and 7.36±4.71 pg/mg, respectively). Plasma ET-1 levels were significantly lower in patients with AIH (0.84±0.64 pg/ml) than in controls (1.54±0.54 pg/ml, P=0.0001). In conclusion, patients with AIH had increased urinary ET-1 excretion and decreased plasma ET-1 levels. This is most likely due to the decreased reabsorption of ET-1 in the renal tubule and increased renal production.

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Authors and Affiliations

  1. First Pediatric Department, Athens University Medical School, “Aghia Sophia” Children’s Hospital, Athens, Greece

    Polyxeni Nicolaidou & Fotini Psychou

  2. Second Pediatric Department, Athens University Medical School, “Aglaia Kyriakou” Children’s Hospital, Athens, Greece

    Helen Georgouli, Helen Tsapra, Petros M. Zeis & Dimitris Gourgiotis

  3. Pediatric Department, “Chatzicosta” Hospital, Ioannina, Greece

    Vasiliki Getsi

  4. Department of Environmental Sciences, University of the Aegean, Mytilene, Greece

    Yiannis G. Matsinos

  5. First Pediatric Department, Athens University Medical School, “Aghia Sophia” Children’s Hospital, Thivon and Levadias str., 115 27 Athens, Greece

    Polyxeni Nicolaidou

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  1. Polyxeni Nicolaidou
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  2. Helen Georgouli
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  3. Vasiliki Getsi
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  4. Helen Tsapra
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  5. Fotini Psychou
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  8. Dimitris Gourgiotis
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Correspondence to Polyxeni Nicolaidou.

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Nicolaidou, P., Georgouli, H., Getsi, V. et al. Urinary excretion of endothelin-1 in children with absorptive idiopathic hypercalciuria. Pediatr Nephrol 18, 1157–1160 (2003). https://doi.org/10.1007/s00467-003-1263-5

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  • DOI: https://doi.org/10.1007/s00467-003-1263-5

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