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Focal segmental membranoproliferative glomerulonephritis in children

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Abstract

Eight patients with focal segmental membranoproliferative glomerulonephritis (FSMPGN) were followed for 5–16 years. Their urinary abnormalities were detected by school urinary screening in seven, and one patient presented with nephrotic syndrome. All but one patient were treated with alternate-day (ALD) prednisolone. With time, urinalysis became normal in six and two continued to have proteinuria with or without hematuria. Serum albumin, cholesterol, and creatinine levels were normal at the last follow-up. Serum C3 returned to normal levels in six, but remained persistently decreased in two. Mesangial proliferation and matrix changes in glomeruli without MPGN lesions were mild. Subendothelial and mesangial electron-dense deposits and deposits containing C3 along capillary walls and mesangium were observed. MPGN lesions and mesangial proliferation improved. No severe growth retardation was observed, but the duration and dosage of ALD prednisolone could be reduced further, since the patients with FSMPGN seemed to have an excellent prognosis.

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Acknowledgement

The authors wish to express appreciation to Dr. Nobuo Matsuura for reviewing this paper.

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Authors and Affiliations

  1. Department of Pediatrics, Yamato City Hospital, 8–3-6 Fukaminishi Yamato-shi, Kanagawa 242–8602, Japan

    Kikuo Iitaka

  2. Department of Pediatrics, Kitasato University Hospital, 1–15–1 Kitasato, Sagamihara-shi, Kanagawa 228–8555, Japan

    Kikuo Iitaka, Shinya Nakamura & Shunsuke Moriya

  3. Department of Pediatrics, Toho University Hospital, 6–11–1 Omorinishi, Ota-ku, Tokyo 143–0015, Japan

    Osamu Motoyama

  4. Children's Kidney Center, Shizugin Nissei Nakayama Building 5F, 306–5 Nakayama, Midori-ku, Yokohama, Kanagawa 226–0011, Japan

    Tadasu Sakai

Authors
  1. Kikuo Iitaka
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  2. Shinya Nakamura
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  3. Shunsuke Moriya
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  4. Osamu Motoyama
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  5. Tadasu Sakai
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Correspondence to Kikuo Iitaka.

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Iitaka, K., Nakamura, S., Moriya, S. et al. Focal segmental membranoproliferative glomerulonephritis in children. Pediatr Nephrol 18, 1000–1004 (2003). https://doi.org/10.1007/s00467-003-1231-0

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  • DOI: https://doi.org/10.1007/s00467-003-1231-0

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