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Low serum apolipoprotein AI levels in amyloidosis related to familial Mediterranean fever

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Abstract

Amyloidosis (A) related to familial Mediterranean fever (FMF) causes serious morbidity and mortality in children. Our study evaluates serum levels of apolipoprotein (Apo) AI, AII, B, and E and Apo AII/AI ratios as a non-invasive diagnostic tool for amyloidosis in children with FMF and FMF-A. Results were compared with those of patients with childhood nephrotic syndrome (NS) and healthy children (controls). Significantly lower serum levels of Apo AI (90.20±28.30 mg/dl) were documented in patients with FMF-A than in all other groups (FMF 126.89±51.07 mg/dl, NS 140.38±33.73 mg/dl, and controls 134.67±12.73 mg/dl) (P<0.01). Diagnostic sensitivity, specificity, and predictive value for this test were 85%, 80%, and 85%, respectively. Apo AII/AI ratio results were essentially equal in all groups (P>0.05). It is concluded that a decreased Apo AI serum level, but not Apo AII/AI ratio, is a useful, non-invasive test for the early diagnosis of FMF-A in children.

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Acknowledgement

The authors wish to thank the critical review of the statistical analysis of Professor Dr. Yuksel Bek and Dr. Sevgi Canbaz.

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Authors and Affiliations

  1. Department of Pediatrics, Ondokuz Mayis University, 55139 Samsun, Turkey

    İsmail İşlek, Tülin Şimşek, Behçet Şimşek & Şükrü Küçüködük

  2. Department of Pediatric Nephrology, Başkent University, Ankara, Turkey

    Esra Baskın & Ümit Saatçi

  3. Department of Biochemistry, Ondokuz Mayis University, Samsun, Turkey

    Abdülkerim Bedir

  4. Department of Pediatric Nephrology, Hacettepe University, Ankara, Turkey

    Ayşin Bakkaloğlu, Nesrin Beşbaş, Rezzan Topaloğlu & Seza Özen

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  1. İsmail İşlek
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  2. Tülin Şimşek
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  3. Esra Baskın
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  4. Behçet Şimşek
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  5. Şükrü Küçüködük
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  6. Abdülkerim Bedir
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  7. Ayşin Bakkaloğlu
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  8. Nesrin Beşbaş
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  9. Rezzan Topaloğlu
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  10. Seza Özen
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  11. Ümit Saatçi
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Correspondence to İsmail İşlek.

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İşlek, İ., Şimşek, T., Baskın, E. et al. Low serum apolipoprotein AI levels in amyloidosis related to familial Mediterranean fever. Pediatr Nephrol 18, 1005–1008 (2003). https://doi.org/10.1007/s00467-003-1227-9

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  • DOI: https://doi.org/10.1007/s00467-003-1227-9

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