Abstract.
Stevens-Johnson syndrome (SJS) is a mucocutaneous disease that can be lethal. It can occur in association with altered immunological conditions and the administration of various drugs, including corticosteroids. We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks. He presented symptoms of fever, skin lesions consisting of multiple vesiculopapular rashes, pruritic maculae and bullae, and mucosal involvement of the eyes, lips, oral cavity, and anorectal junction. His condition improved without complications following the discontinuation of oral prednisolone and replacement with intravenous methylprednisolone. Following the improvement of the symptoms of SJS, he received alternate-day oral prednisolone without any cutaneous eruption.
This is a preview of subscription content, log in via an institution to check access.
References
Habif TP (1996) Clinical dermatology, 3rd edn. Mosby Yearbook, St. Louis, pp 566–596
Rasmussen JE (2002) Erythema multiforme: a practical approach to recent advances. Pediatr Dermatol 19:82–84
Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F, Mockenhaupt M, Paoletti C, Shapiro S, Shear N, Schöpf E, Kaufman DW (1995) Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 333:1600–1607
Patterson R, Dykewicz MS, Gonzalzles A, Grammer LC, Green D, Greenberger PA, McGrath KG, Walker CL (1990) Erythema multiforme and Stevens-Johnson syndrome. Descriptive and therapeutic controversy. Chest 98:331–336
Martinez AE, Atherton DJ (2000) High-dose systemic corticosteroids can arrest recurrences of severe mucocutaneous erythema multiforme. Pediatr Dermatol 17:87–90
Samimi SS, Siegfried E (2002) Stevens-Johnson syndrome developing in a girl with systemic lupus erythematosus on high dose corticosteroid therapy. Pediatr Dermatol 19:52–55
Sullivan JR, Shear NH (2001) The drug hypersensitivity syndrome. What is the pathogenesis? Arch Dermatol 137:357–364
Roujeau JC, Stern RS (1994) Severe adverse cutaneous reactions to drugs. N Engl J Med 331:1272–1285
Assier-Bonnet H, Aractingi S, Cadranel J, Wechsler J, Mayaud C, Saiag P (1996) Stevens-Johnson syndrome induced by cyclophosphamide: report of two cases. Br J Dermatol 135:852–866
Duarte AM (2000) Proceedings of the 1999 meeting of the Society for Pediatric Dermatology. Pediatr Dermatol 1:75–83
Kakourou T, Klontza D, Soteropoulou F, Kattamis C (1997) Corticosteroid treatment of erythema multiforme major (Stevens-Johnson syndrome) in children. Eur J Pediatr 156:90–93
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jo, D.S., Yang, JW., Hwang, P.H. et al. Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy. Pediatr Nephrol 18, 959–961 (2003). https://doi.org/10.1007/s00467-003-1215-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-003-1215-0