Abstract
Crescentic glomerulonephritis (CGN) is a clinicopathologic entity which is characterized by severe renal dysfunction of rapid onset with glomerular crescents. Type III CGN is associated with the absence of glomerular immune complex deposition (pauci-immune) and is associated with antineutrophil cytoplasmic antibody (ANCA). Microscopic polyangiitis and idiopathic pauci-immune necrotizing glomerulonephritis (NCGN) are strongly associated with ANCA directed against myeloperoxidase (anti-MPO). We describe here an unusual pediatric patient with MPO-ANCA-associated rapidly progressive glomerulonephritis (RPGN), emphasizing the management and outcome of the disease.
Similar content being viewed by others
References
Franssen CF, Stegeman CA, Kallenberg CG, Gans RO, De Jong PE, Hoorntje SJ, Tervaert JW (2000) Antiproteinase 3- and antimyeloperoxidase-associated vasculitis. Kidney Int 57:2195–2206
Jennette JC, Wilkman AS, Falk RJ (1998) Diagnostic predictive value of ANCA serology. Kidney Int 53:796
Bakkaloglu A, Ozen S, Baskin E, Besbas N, Gur-Guven A, Kasapcopur O, Tinaztepe K (2001) The significance of antineutrophil cytoplasmic antibody in microscopic polyangiitis and classic polyarteritis nodosa. Arch Dis Child 85:427–430
Guillevin L, Durand-Gasselin B, Cevallos R, Gayraud M, Lhote F, Callard P, Amouroux J, Casassus P, Jarrousse B (1999) Microscopic polyangiitis clinical and laboratory findings in eighty-five patients. Arthritis Rheum 42:421–430
Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG, et al. (1994) Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 37:187–192
Falk RJ, Jennette JC (1997) ANCA small vessel vasculitis. J Am Soc Nephrol 8:315–322
Pradhan M, Meyers KEC, Guttenberg M, Kaplan BS (2000) Wegener's granulomatosis—an atypical case. Pediatr Nephrol 14:862–871
Besbaş N, Ozen S, Saatçi U, Topaloglu R, Tınaztepe K, Bakkaloglu A (2000) Renal involvement in polyarteritis nodosa: evaluation of 26 Turkish children. Pediatr Nephrol 14:325–327
Turner AN, Rees AJ (1998) Antiglomerular basement membrane disease. In: Davison AN, Cameron JS, Grünfeld JP, Kerr DNS, Ritz E, Winearls CG (eds) Oxford textbook of nephrology, 2nd edn. Oxford University Press, Oxford, pp 647–666
Bolton WK, Sturgill WC (1989) Methyl prednisolone therapy for acute crescentic rapidly progressive glomerulonephritis. Am J Nephrol 9:368–375
Levy JB, Winearls CG (1994) Rapidly progressive glomerulonephritis: what should be first line therapy? Nephron 67:402–407
Rasmussen N, Cayne DRW (1998) Review of the activities of the European Vasculitis Study Group (EUVAS). Clin Exp Immunol 112 (Suppl 1):13–15
Savige J, Davies D, Falk RJ, Jennette C, Wiik A (2000) Antineutrophil cytoplasmic antibodies and associated diseases: a review of the clinical and laboratory features. Kidney Int 57:846–862
Kallenberg CGM, Brouwer E, Weening JJ, Cohen Tervaert JW (1994) ANCA: current diagnostic and pathophysiologic potential. Kidney Int 46:1–15
Jayne DRW, Gaskin G, Pusey CD, Lockwood CM (1995) ANCA and predicting relapse in systemic vasculitis. Q J Med 88:127–133
Nyberg G, Akesson P, Norden G, Wieslander J (1997) Systemic vasculitis in kidney transplant population. Transplantation 63:1273–1277
Allen A, Pusey C, Gaskin G (1998) Outcome of renal replacement therapy in antineutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol 9:1258–1263
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Besbas, N., Ozaltin, F., Tınaztepe, K. et al. Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis. Pediatr Nephrol 18, 696–699 (2003). https://doi.org/10.1007/s00467-003-1114-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-003-1114-4