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Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis

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Abstract 

We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.

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Authors and Affiliations

  1. University Children"s Hospital, Mathildenstrasse 1, 79106 Freiburg, Germany e-mail: berner@kikli.ukl.uni-freiburg.de Tel.: +49-761-2704300, Fax: +49-761-2704481, Germany

    R. Berner, Martin F. Krause, Nader Gordjani, Marcus Krueger, Matthias Brandis & Lothar B. Zimmerhackl

  2. Hans-Knöll Institute for Natural Products Research, Beutenbergstrasse 11a, 07745 Jena, Germany, Germany

    Peter F. Zipfel

  3. Institute of Pathology, Albertstrasse 19, 79110 Freiburg, Germany, Germany

    Norbert Boehm

Authors
  1. R. Berner
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  2. Martin F. Krause
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  3. Nader Gordjani
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  4. Peter F. Zipfel
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  5. Norbert Boehm
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  6. Marcus Krueger
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  7. Matthias Brandis
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  8. Lothar B. Zimmerhackl
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Additional information

Received: 13 July 2000 / Revised: 3 October 2001 / Accepted: 9 October 2001

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Berner, R., Krause, M., Gordjani, N. et al. Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis. Pediatr Nephrol 17, 190–192 (2002). https://doi.org/10.1007/s00467-001-0798-6

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  • DOI: https://doi.org/10.1007/s00467-001-0798-6

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