Abstract
Background: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. Methods: Esophageal manometry and 24-h gastroesophageal pH monitoring with event data were performed in 18 mongrel dogs with a cervical esophagopexy. We then calculated a modified DeMeester score: The Duke Canine reflux score (DCR). Thereafter, the animals underwent a 4-cm anterior distal esophageal myotomy, incision of the left diaphragmatic crus, and intrathoracic gastric cardiopexy. Postoperative 24-h pH and manometry were obtained 2 weeks later. Results: The postoperative 24-h pH results showed a significant increase in the mean DCR score (5.9 ± 4.5 vs 84.9 ± 56.1, p < 0.0002), and manometry indicated a significant decrease in mean lower esophageal sphincter (LES) pressure (7.1 ± 2.9 vs 3.2 ± 2.5 mmHg, p < 0.0001). Conclusion: This technique reliably creates a canine model of GERD.
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McMahon, R., Ali, A., Chekan, E. et al. A canine model of gastroesophageal reflux disease (GERD). Surg Endosc 16, 67–74 (2002). https://doi.org/10.1007/s004640080153
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DOI: https://doi.org/10.1007/s004640080153