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Efficacy and safety of salvage endoscopy in the treatment of residual or recurrent colorectal neoplasia after endoscopic resection: a systematic review and meta-analysis

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Abstract

Objective

To systematically review and meta-analyze the efficacy and safety of salvage endoscopy for residual or recurrence of colorectal tumors after endoscopic resection.

Methods

Multiple databases including PubMed, EMBASE and the Cochrane Library were searched to screen for eligible studies and perform data extraction and pooled analysis.

Results

Sixteen studies on salvage endoscopy for residual or recurrent colorectal cancer after endoscopic resection were included, covering approximately 994 patients. The results of the meta-analysis demonstrated that salvage endoscopic therapy for residual or recurrent colorectal tumors following endoscopic resection achieved an en bloc resection rate of 92% (95% CI 0.85–0.97; I2 = 91%) and an R0 resection rate of 82% (95% CI 0.75–0.87; I2 = 78%). The rates of intraoperative or postoperative bleeding and perforation were 10%/1% and 5%/2%, and the recurrence rate was 2%.

Conclusions

Salvage endoscopic resection is an effective and safe treatment strategy for residual or recurrent colorectal tumors after endoscopic resection.

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Authors and Affiliations

  1. Department of Gastroenterology, Meishan City People’s Hospital, Meishan, Sichuan, China

    Juan Du, Ting Zhang, Lei Wang & Wenquan Yi

  2. Department of Hepatobiliary and Pancreatic Surgery, Meishan City People’s Hospital, Meishan, Sichuan, China

    Hao Zhang

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Correspondence to Wenquan Yi.

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Juan Du, Ting Zhang, Lei Wang, Hao Zhang, Wenquan Yi have no confict of interest or fnancial ties to disclose.

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This meta-analysis has been registered on Prospero (https://www.crd.york.ac.uk/PROSPERO) as CRD42024522911.

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Du, J., Zhang, T., Wang, L. et al. Efficacy and safety of salvage endoscopy in the treatment of residual or recurrent colorectal neoplasia after endoscopic resection: a systematic review and meta-analysis. Surg Endosc 38, 3027–3034 (2024). https://doi.org/10.1007/s00464-024-10879-8

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