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TAVAC: comprehensive review of currently available hemostatic products as adjunct to surgical hemostasis

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Abstract

Background

The use of hemostatic agents by general surgeons during abdominal operations is commonplace as an adjunctive measure to minimize risks of postoperative bleeding and its downstream complications. Proper selection of products can be hampered by marginal understanding of their pharmacokinetics and pharmacodynamics. While a variety of hemostatic agents are currently available on the market, the choice of those products is often confusing for surgeons. This paper aims to summarize and compare the available hemostatic products for each clinical indication and to ultimately better guide surgeons in the selection and proper use of hemostatic agents in daily clinical practice.

Methods

We utilized PubMed electronic database and published product information from the respective pharmaceutical companies to collect information on the characteristics of the hemostatic products.

Results

All commercially available hemostatic agents in the US are described with a description of their mechanism of action, indications, contraindications, circumstances in which they are best utilized, and expected results.

Conclusion

Hemostatic products come with many different types and specifications. They are valuable tools to serve as an adjunct to surgical hemostasis. Proper education and knowledge of their characteristics are important for the selection of the right agent and optimal utilization.

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Author information

Authors and Affiliations

  1. Digestive Health Institute, AdventHealth Tampa, Tampa, FL, USA

    Iswanto Sucandy, Sharona Ross & Maria Christodoulou

  2. Stanford University, Palo Alto, CA, USA

    Jonathan DeLong

  3. University of California Irvine, Irvine, CA, USA

    Michael Tran

  4. Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Fred Qafiti

  5. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Bayshore, NY, USA

    David Pechman

  6. Sentara Martha Jefferson Medical And Surgical Associates, Charlottesville, VA, USA

    Tim Snow

  7. University of South Florida, Tampa, FL, USA

    Salvatore Docimo & Allyson Lim-Dy

  8. The Ohio State University Wexner Medical Center, Columbus, OH, USA

    David Renton

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  1. Iswanto Sucandy
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Correspondence to Iswanto Sucandy.

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Disclosure

Dr Salvatore Docimo receives honorarium from Boston Scientific, Medtronic, and BD. Dr. Sharona Ross is a member of the Advisory Board for Intuitive Surgical Inc. Drs. Iswanto Sucandy, Jonathan DeLong, Michael Tran, Fred Qafiti, David Pechman, Tim Snow, Allyson Lim-Dy, Maria Christodoulou and David Renton have no financial interests to disclose.

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Sucandy, I., Ross, S., DeLong, J. et al. TAVAC: comprehensive review of currently available hemostatic products as adjunct to surgical hemostasis. Surg Endosc (2024). https://doi.org/10.1007/s00464-024-10806-x

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