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Comparison of weight loss after Roux-en-Y gastric bypass in Helicobacter pylori-negative and Helicobacter pylori eradicated patients during five years follow-ups

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Abstract

Purpose

Helicobacter pylori (HP) is the most common human infection that has affected up to 50% of the population worldwide. The relationship between HP eradication and weight loss is under debate. The present study aimed to compare weight loss outcomes after Roux-en-Y gastric bypass (RYGB) in HP-negative (HP−) and HP-eradicated (HPe) patients during five years follow-ups.

Methods

This retrospective cohort study was conducted on 305 patients aged 18 and more with severe obesity, who underwent primary RYGB from February 2014 to November 2017. The HP-negative and HP-eradicated patients were evaluated for weight loss outcomes during five years follow-ups.

Results

Patients' mean age, mean weight, and mean body mass index were 38.78 ± 9.9, 114.8 ± 13.6, and 43.37 ± 2.55, respectively. 27.2% of patients who were HP-positive were treated before RYGB. There was no significant difference between the HP− and HPe patients in terms of total weight loss percent (%TWL), 12 to 60 months after RYGB. Excess weight loss percent (%EWL) was higher in HPe patients compared to HP− patients (P = 0.04) at 12-month after RYGB. However, there was no difference in %EWL between these two groups of patients, 36 and 60 months after RYGB.

Conclusion

The results of the present study showed that TWL% had no significant difference in HP− and HPe groups during five years follow-ups after RYGB. The %EWL was higher in HPe patients only at 12 months after RYGB and the difference did not persist over time.

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Data availability

The authors confirm that the data supporting the findings of this study are available within the article.

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Authors and Affiliations

  1. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran

    Behnood Farazmand & Masoumeh Shahsavan

  2. Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Rasool-E Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Foolad Eghbali, Abdolreza Pazouki & Mohammad Kermansaravi

  3. Center of Excellence of European Branch of International Federation for Surgery of Obesity, Hazrat_e Rasool Hospital, Tehran, Iran

    Foolad Eghbali, Abdolreza Pazouki & Mohammad Kermansaravi

Authors
  1. Behnood Farazmand
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  2. Masoumeh Shahsavan
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  3. Foolad Eghbali
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  4. Abdolreza Pazouki
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  5. Mohammad Kermansaravi
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Correspondence to Masoumeh Shahsavan or Mohammad Kermansaravi.

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Drs Behnood Farazmand, Masoumeh Shahsavan, Foolad Eghbali, Abdolreza Pazouki and Mohammad Kermansaravi, have no conflicts of interest or financial ties to disclose.

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Farazmand, B., Shahsavan, M., Eghbali, F. et al. Comparison of weight loss after Roux-en-Y gastric bypass in Helicobacter pylori-negative and Helicobacter pylori eradicated patients during five years follow-ups. Surg Endosc 38, 888–893 (2024). https://doi.org/10.1007/s00464-023-10578-w

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  • DOI: https://doi.org/10.1007/s00464-023-10578-w

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