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Robotic versus open pancreatoduodenectomy in patients with pancreatic duct adenocarcinoma after the learning curve: a propensity score-matched analysis

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Abstract

Background

Studies have demonstrated that the learning curve plays an important role in robotic pancreatoduodenectomy (RPD). Although improved short-term outcomes of RPD after the learning curve have been reported compared to open pancreatoduodenectomy (OPD), there is a lack of long-term survival analyses.

Methods

Patients who underwent curative intended RPD and OPD for pancreatic duct adenocarcinoma (PDAC) between January 2017 and June 2020 were retrospectively reviewed. A 1:2 propensity score matching (PSM) analysis was performed to balance the baseline characteristics between the RPD and OPD groups.

Results

Of the 548 patients (108 RPD and 440 OPD), 103 RPD patients were matched with 206 OPD patients after PSM. There were 194 (62.8%) men and 115 (37.2%) women, with a median age of 64 (58–69) years. The median overall survival (OS) in the RPD group was 33.2 months compared with 25.7 months in the OPD group (p = 0.058, log-rank). The median disease-free survival (DFS) following RPD was longer than the OPD (18.5 vs. 14.0 months, p = 0.011, log-rank). The RPD group has a lower incidence of local recurrence compared the OPD group (36.9% vs. 51.2%, p = 0.071). Multivariate Cox analysis demonstrated that RPD was independently associated with improved OS (HR 0.70, 95% CI 0.52–0.94, p = 0.019) and DFS (HR 0.66, 95% CI 0.50–0.88, p = 0.005).

Conclusion

After the learning curve, RPD had improved oncologic outcomes in PDAC patients compared to OPD. Future prospective randomized clinical trials will be required to validate these findings.

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Author notes

  1. Haoda Chen, Yuanchi Weng, and Shulin Zhao have contributed equally to this work.

Authors and Affiliations

  1. Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China

    Haoda Chen, Yuanchi Weng, Shulin Zhao, Weishen Wang, Yuchen Ji, Chenghong Peng, Xiaxing Deng & Baiyong Shen

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  1. Haoda Chen
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Haoda Chen, Yuanchi Weng, Shulin Zhao, Weishen Wang, Yuchen Ji, Chenghong Peng, Xiaxing Deng, and Baiyong Shen have no conflict of interest or financial ties to disclose.

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Chen, H., Weng, Y., Zhao, S. et al. Robotic versus open pancreatoduodenectomy in patients with pancreatic duct adenocarcinoma after the learning curve: a propensity score-matched analysis. Surg Endosc 38, 821–829 (2024). https://doi.org/10.1007/s00464-023-10530-y

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