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The role of intraoperative pancreatoscopy in the surgical management of intraductal papillary mucinous neoplasms of the pancreas: a systematic scoping review

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Abstract

Background

The type and the extent of surgery is still debatable for intraductal papillary mucinous neoplasm (IPMN). Intraoperative pancreatoscopy (IOP) allows the visualization of the main pancreatic duct (MPD) in its entire length and could help determine the extent of MPD involvement and the type and extent of pancreatic resection. However, current guidelines do not advise its routine use as there is a lack of evidence supporting its safety and feasibility. The present study aims to perform a scoping review of published evidence on the safety and feasibility of IOP in IPMN surgical management.

Methods

We systematically searched PubMed, Cochrane, Medline and EMbase to identify studies reporting the use of IOP in IPMN surgical management. The research was completed in June 2023. Data extracted included patient selection criteria, demographics, safety of the procedure, intraoperative findings, impact on surgical strategy, histology results and postoperative outcomes.

Results

Four retrospective and one prospective study were included in this scoping review. A total of 142 patients had IOP. The selection criteria for inclusion were heterogenous, with one out of five studies including branch duct (BD), main duct (MD) and mixed type IPMN. Indications for IOP and surgical resection were only reported in two studies. A median of seven outcomes (range 5–8) was described, including the type of surgical resection, additional lesions and change of surgical plan, and complications after IOP. IOP showed additional lesions in 48 patients (34%) and a change of surgical plan in 48(34%). No IOP-related complications were reported.

Conclusions

This scoping review suggests IOP is safe and identifies additional lesions impacting the surgical strategy for IPMN. However, the included studies were small and heterogeneous regarding IPMN definition and indications for surgery and IOP. There is a need for a large multi-centre prospective study to determine the role of IOP and its impact on surgical strategy for IPMN.

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Authors and Affiliations

  1. Department of HPB Surgery, University Hospitals Plymouth NHS Trust, Plymouth, UK

    Debora Ciprani, Hoda Amar & Somaiah Aroori

  2. Department of HPB Surgery, Royal Surrey County NHS Foundation Trust, Guildford, UK

    Adam Frampton

  3. HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, UK

    Kofi Oppong & Sanjay Pandanaboyana

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  1. Debora Ciprani
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  2. Adam Frampton
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  3. Hoda Amar
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Correspondence to Somaiah Aroori.

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Debora Ciprani, Hoda Amar, Adam Frampton, Oppong Kofi, Sanjay Pandanaboyana, and Somaiah Aroori have no conflicts of interest or financial ties to disclose.

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Ciprani, D., Frampton, A., Amar, H. et al. The role of intraoperative pancreatoscopy in the surgical management of intraductal papillary mucinous neoplasms of the pancreas: a systematic scoping review. Surg Endosc 37, 9043–9051 (2023). https://doi.org/10.1007/s00464-023-10518-8

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