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Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study

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A Correction to this article was published on 31 October 2023

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Abstract

Background

Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the n-hexyl cyanoacrylate glue Ifabond™ for mesh fixation in laparoscopic inguinal hernia repair.

Methods

This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond™ (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh® SURG ST (Peters Surgical)/Biomesh® P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh® SURG LI (Peters Surgical)/Premium® Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.

Results

Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 ± 10.04; p < 0.0001) and 12-month (3.83 ± 11.26; p < 0.0001) follow-up compared with before surgery (26.96 ± 19.42). One hundred and fifteen patients (13.74%) experienced chronic pain in the groin at 12-month follow-up, of whom 14 (2.67%) required analgesics. There were 6 patients with major morbidities and one patient died of an unrelated cause. Two hernia recurrences occurred within 12-month follow-up. Patients’ QoL increased from an EQ-5D-3L index score of 0.82 ± 0.19 preoperatively to 0.90 ± 0.15 at 5 weeks (p < 0.0001) and 0.92 ± 0.15 at 12 months after surgery (p < 0.0001). The EQ-VAS general health scoring increased from 79.03 ± 12.69 preoperatively to 84.31 ± 9.97 at 5-week (p < 0.0001) and 84.16 ± 14.48 at 12-month follow-up (p < 0.0001).

Conclusions

Ifabond™ (Peters Surgical) is a safe, reliable, and feasible fixation method for laparoscopic inguinal hernia repair with a very high surgeon satisfaction score, improved patients’ QoL, and comparable risk of developing chronic pain and postoperative complications as described in the literature.

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Acknowledgements

The authors would like to thank Lieselot Rosseel, Marlinde de Wit, Hannelore Cooreman, and Dorien Vermeulen for their assistance in data collection and study management.

Funding

This study received funding from Duomed (Aartselaar, Belgium).

Author information

Authors and Affiliations

  1. Department of Abdominal Surgery, Ziekenhuis Oost-Limburg, Genk, Belgium

    Anne Dams & Kurt Van der Speeten

  2. Department of General and Abdominal Surgery, Regional Hospital Heilig Hart, Tienen, Belgium

    Joost Vankeirsbilck, Stephan Poelmans, Ivan Kerschaever & Philippe Borreman

  3. Department of General Surgery, Hospital Sint-Vincentius, Deinze, Belgium

    Luc Berwouts, Wim De Mulder & Julien Colle

  4. Department of Abdominal Surgery, Antwerp University Hospital, Edegem, Belgium

    Anthony Beunis & Vicky Dhooghe

  5. Department of Abdominal Surgery, UZ Brussel, Brussels, Belgium

    Nele Van De Winkel, Mathias Allaeys & Michael Ruyssers

  6. Archer Research CRO, Diepenbeek, Belgium

    Dorien Haesen

  7. Faculty of Medicine, Hasselt University, Diepenbeek, Belgium

    Kurt Van der Speeten

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  1. Anne Dams
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Correspondence to Kurt Van der Speeten.

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Disclosures

Kurt Van der Speeten and Anne Dams are consultants for Duomed. Joost Vankeirsbilck, Stephan Poelmans, Ivan Kerschaever, Philippe Borreman, Luc Berwouts, Wim De Mulder, Julien Colle, Anthony Beunis, Vicky Dhooghe, Nele Van De Winkel, Mathias Allaeys, Michael Ruyssers, and Dorien Haesen have no conflicts of interest or financial ties to disclose.

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Dams, A., Vankeirsbilck, J., Poelmans, S. et al. Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study. Surg Endosc 37, 9105–9115 (2023). https://doi.org/10.1007/s00464-023-10439-6

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