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Association of clinical characteristics and recurrence of conventional colorectal adenomas with patient age: a single-center study

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Abstract

Objectives

We performed a clinical study comparing early-onset and late-onset conventional colorectal adenomas (CCRAs) since little is known about the differences in their characteristics.

Methods

Pearson’s chi-square test and the Kruskal‒Wallis test were used to compare basic information. MCAR tests and multiple imputation were performed to complete missing values. Multivariate logistic analysis and propensity score matching were used to identify the risk factors for recurrence.

Results

We included 2793 patients (688 with early-onset CCRAs and 2105 with late-onset CCRAs) from January 2017 to December 2021. Patients with early-onset CCRAs had higher levels of Hb, ALB, and triglycerides but lower HDL levels and N/L ratios. Moreover, we found that more early-onset CCRAs were in the left colon than late-onset CCRAs, and the size of early-onset CCRAs was larger. Early-onset CCRAs tended to lack pedicles compared to late-onset CCRAs. Additionally, the ratio of EMR and APC in early-onset CCRAs was higher than that in late-onset CCRAs, and the ratio of ESD and surgery for late-onset CCRAs was higher. We found that age ≥ 50 years, abnormal vessels, drinking alcohol, and DB and ALB levels may be risk factors for recurrence, while the LDL level may be a protective factor. Finally, analysis of cumulative recurrence rates after PSM showed that patients with late-onset CCRAs exhibited higher recurrence rates (P < 0.05).

Conclusion

Compared with late-onset CCRAs, early-onset CCRAs were associated with higher triglyceride levels, lower HDL levels, and larger tumor volumes. Age ≥ 50 years, abnormal vessels, alcohol consumption, and DB and ALB levels were independent risk factors for recurrence of CCRAs.

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Data availability

All data generated or analyzed during this study are included in this published article and its supplementary information file.

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Authors and Affiliations

  1. Department of Integration of Traditional Chinese and Western Medicine and Anorectum, The First Affiliated Hospital of Nanchang University, Nanchang, China

    Peng Liao & Wu-hua Huang

  2. Department of Rheumatology and Immunology Department, The First Affiliated Hospital of Nanchang University, Nanchang, China

    Li-ming Chen

  3. Medical College of Nanchang University, Nanchang, China

    Sheng Zhou

  4. Prevention and Treatment Center, The First Affiliated Hospital of Nanchang University, Nanchang, China

    Mingyun Ma

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  1. Peng Liao
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Contributions

PL and LC: experiment performing, data analysis, and manuscript writing. WH and SZ: sample collecting and data analysis. MM: project development.

Corresponding author

Correspondence to Mingyun Ma.

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Disclosures

Peng Liao, Li-ming Chen Wu-hua Huang, Sheng Zhou and Mingyun Ma have no conflicts of interest or financial ties to disclose.

Ethical approval

Our study was approved by Ethics Committee of the First Affiliated Hospital of Nanchang University (2022-4-023). All methods were carried out in accordance with relevant guidelines and regulations.

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Liao, P., Chen, Lm., Huang, Wh. et al. Association of clinical characteristics and recurrence of conventional colorectal adenomas with patient age: a single-center study. Surg Endosc 37, 8373–8383 (2023). https://doi.org/10.1007/s00464-023-10352-y

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  • DOI: https://doi.org/10.1007/s00464-023-10352-y

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