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Effectiveness and safety of novel motorized spiral enteroscopy: a systematic review and meta-analysis

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Abstract

Background

Motorized spiral enteroscopy (MSE) is a novel advance in small bowel examination that is characterized as fast with a deep insertion. The aim of this study was to elucidate the effectiveness and safety of MSE.

Methods

Relevant articles that were published before November 1, 2022 were identified by searching PubMed, EMBASE, Cochrane, and the Web of Science. The technical success rate (TSR), total (pan)-enteroscopy rate (TER), depth of maximum insertion (DMI), diagnostic yield, and adverse events were extracted and analyzed. Forest plots were graphed based on random effects models.

Results

A total of 876 patients from 8 studies were eligible for analysis. The pooled results of the TSR were 95.0% [95% confidence interval (CI) 91.0–98.0%, I2 = 78%, p < 0.01] and the pooled outcome of the TER was 43.1% (95% CI 24.7–62.5%, I2 = 95%, p < 0.01). The pooled results of the diagnostic and therapeutic yields were 77.2% (95% CI 69.0–84.5%, I2 = 84%, p < 0.01) and 49.0% (95% CI 38.0–60.1%, I2 = 89%, p < 0.01), respectively. The pooled estimates of adverse and severe adverse events were 17.2% (95% CI 11.9–23.2%, I2 = 75%, p < 0.01) and 0.7% (95% CI 0.0–2.1%, I2 = 37%, p = 0.13), respectively.

Conclusion

MSE is a novel alternative approach for small bowel examination that can achieve high TER and diagnostic and therapeutic yields, and relatively low rates of severe adverse events. Head-to-head studies comparing MSE and other device-assisted enteroscopies are warranted.

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Funding

Yizi Wang has received research funding by 345 Talent Project from Shengjing Hospital of China Medical University and Basic Scientific Research Project of Education Department of Liaoning Province.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China

    Yizi Wang

  2. Department of Colorectal Surgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, No. 44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, People’s Republic of China

    Bin Ma

  3. Department of Thoracic Surgery, The First Hospital of China Medical University, No.155 North Nanjing Street, Shenyang, 110001, People’s Republic of China

    Wenya Li & Peiwen Li

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  1. Yizi Wang
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  4. Peiwen Li
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Correspondence to Peiwen Li.

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Dr. Yizi Wang, Dr. Bin Ma, Dr. Wenya Li and Dr. Peiwen Li have no conflicts of interest.

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Wang, Y., Ma, B., Li, W. et al. Effectiveness and safety of novel motorized spiral enteroscopy: a systematic review and meta-analysis. Surg Endosc 37, 6998–7011 (2023). https://doi.org/10.1007/s00464-023-10179-7

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  • DOI: https://doi.org/10.1007/s00464-023-10179-7

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