Abstract
Background
Recent years there have been witnessed considerable advances in endoscopic selective lateral neck dissection (LND). However, dissection of lymph nodes at level IV and level VI via the chest approach is inherently challenging. In this study, we used combined trans-oral and chest approach for endoscopic thyroidectomy in patients with cT1-2N1bM0 papillary thyroid carcinoma (PTC).
Methods
Clinical characteristics and surgical outcomes of ten patients with cT1-2N1bM0 PTC who underwent endoscopic thyroidectomy via combination of trans-oral and chest approach between September 2020 and September 2021 were retrospectively reviewed.
Results
All 10 patients successfully underwent total thyroidectomy and selective LND via chest approach, while central neck dissection (CND) and supplementary dissection of lymph nodes at level IV were performed via the trans-oral approach. The mean number of positive/retrieved level II, III-IV, and VI lymph nodes were 0.6 ± 1.0/9.8 ± 5.0, 4.6 ± 2.8/23.1 ± 4.7, and 4.9 ± 3.4/10.3 ± 4.6, respectively. Four patients developed transient hypoparathyroidism which spontaneously resolved within 1 month. Five patients developed numbness of lateral neck and ear and one patient experienced limb lift restriction. No other complications or tumor recurrence occurred during follow-up.
Conclusion
It is feasible to perform total thyroidectomy, CND, and selective LND via combined trans-oral and chest approach, and satisfactory short-term outcomes were observed in this cohort. This approach may offer one more option for cT1-2N1bM0 PTC patients, especially those in whom metastatic lymph nodes at level IV or level VI are detected by preoperative examination.
Graphical abstract
Similar content being viewed by others
References
Hu D, Zhou J, He W, Peng J, Cao Y, Ren H, Mao Y, Dou Y, Xiong W, Xiao Q, Su X (2018) Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma. World J Surg Oncol 16:30
Cracchiolo JR, Wong RJ (2018) Management of the lateral neck in well differentiated thyroid cancer. Eur J Surg Oncol 44:332–337
Ducoudray R, Tresallet C, Godiris-Petit G, Tissier F, Leenhardt L, Menegaux F (2013) Prophylactic lymph node dissection in papillary thyroid carcinoma: is there a place for lateral neck dissection? World J Surg 37:1584–1591
Mulla MG, Knoefel WT, Gilbert J, McGregor A, Schulte KM (2012) Lateral cervical lymph node metastases in papillary thyroid cancer: a systematic review of imaging-guided and prophylactic removal of the lateral compartment. Clin Endocrinol (Oxf) 77:126–131
Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A (2005) Ultrasonographically and anatomopathologically detectable node metastases in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma. World J Surg 29:917–920
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1–133
BC Jr Stack RL Ferris D Goldenberg M Haymart A Shaha S Sheth JA Sosa RP Tufano American Thyroid Association Surgical Affairs Committee (2012) American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer. Thyroid 22:501–508
Inoue H, Nibu K, Saito M, Otsuki N, Ishida H, Onitsuka T, Fujii T, Kawabata K, Saikawa M (2006) Quality of life after neck dissection. Arch Otolaryngol Head Neck Surg 132:662–666
Shah S, Har-El G, Rosenfeld RM (2001) Short-term and long-term quality of life after neck dissection. Head Neck 23:954–961
Guo Y, Qu R, Huo J, Wang C, Hu X, Chen C, Liu D, Chen W, Xiong J (2019) Technique for endoscopic thyroidectomy with selective lateral neck dissection via a chest-breast approach. Surg Endosc 33:1334–1341
Yan HC, Xiang C, Wang Y, Wang P (2020) Scarless endoscopic thyroidectomy (SET) lateral neck dissection for papillary thyroid carcinoma through breast approach: 10 years of experience. Surg Endosc. https://doi.org/10.1007/s00464-020-07814-y
Lin P, Liang F, Cai Q, Han P, Chen R, Xiao Z, Wang J, Huang X (2020) Comparative study of gasless endoscopic selective lateral neck dissection via the anterior chest approach versus conventional open surgery for papillary thyroid carcinoma. Surg Endosc. https://doi.org/10.1007/s00464-020-07434-6
Kalloo AN, Singh VK, Jagannath SB, Niiyama H, Hill SL, Vaughn CA, Magee CA, Kantsevoy SV (2004) Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity. Gastrointest Endosc 60:114–117
Witzel K, von Rahden BH, Kaminski C, Stein HJ (2008) Transoral access for endoscopic thyroid resection. Surg Endosc 22:1871–1875
Xu Z, Song J, Wang Y, Tan L, Sun S, Meng Y (2019) A comparison of transoral vestibular and bilateral areolar endoscopic thyroidectomy approaches for unilateral papillary thyroid microcarcinomas. Wideochir Inne Tech Maloinwazyjne 14:501–508
Tan Y, Guo B, Deng X, Ding Z, Wu B, Niu Y, Hou J, Zhang Y, Fan Y (2020) Transoral endoscopic selective lateral neck dissection for papillary thyroid carcinoma: a pilot study. Surg Endosc 34:5274–5282
Wang CC, Chen J, Hu YZ, Wu DB, Xu YH (2004) Endoscopic thyroidectomy with 150 cases. Zhonghua Wai Ke Za Zhi 42:675–677
Wang CC, Yang JG, Hu YZ, Chen J, Xu P, Su C (2007) Endoscopic thyroidectomy via chest and breasts approach in 500 cases. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:919–923
Chen ZX, Song YM, Chen JB, Zhang XB, Lin ZH, Cai BY, Pang FS, Qin Y (2021) Qin’s seven steps for endoscopic selective lateral neck dissection via the chest approach in patients with papillary thyroid cancer: experience of 35 cases. Surg Endosc. https://doi.org/10.1007/s00464-021-08540-9
Hillel AD, Kroll H, Dorman J, Medieros J (1989) Radical neck dissection: a subjective and objective evaluation of postoperative disability. J Otolaryngol 18:53–61
Acknowledgements
The authors thank Medjaden Bioscience Limited for linguistic revision of the manuscript.
Funding
No funding was received.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Disclosures
Zhen-Xin Chen, Ying Cao, Li-Ming Yang, Jing-Bao Chen, Feng-Shun Pang, Zhan-Hong Lin, Xiao-Bo Zhang, Bei-Yuan Cai, Wei-Wu Zheng, and You Qin have no conflicts of interest or financial ties to disclose.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Chen, ZX., Cao, Y., Yang, LM. et al. Endoscopic thyroidectomy via the combined trans-oral and chest approach for cT1-2N1bM0 papillary thyroid carcinoma. Surg Endosc 36, 9092–9098 (2022). https://doi.org/10.1007/s00464-022-09376-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00464-022-09376-7