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Creation of gastroenteric anastomosis through natural orifice in rats by magnetic compression technique

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Abstract

Background

Being one of the core techniques of magnetic surgery, magnetic compression technique (MCT) has been used for digestive tract anastomosis reconstruction in experimental studies. This study verified the feasibility of gastroenteric anastomosis through natural orifice using MCT in rats.

Methods

The parent and daughter magnets were designed and manufactured for oral and anal insertion in 20 Sprague‐Dawley rats. After anesthesia, the parent magnet was inserted into the colon spleen area through the anus, and the daughter magnet was inserted into the stomach through the mouth. Then the two magnets were positioned to attract each other and bind together. The position of the two magnets was monitored using X-ray. The time required for the formation of the anastomosis and expulsion of the magnets were recorded. 2 weeks later, the animal was sacrificed and the anastomotic specimen was obtained which was observed under naked eye and microscope.

Results

The gastroenteric anastomosis was successfully performed via natural orifices in 18 out of 20 rats. The mean time to construct the anastomosis was 3.78 ± 0.88 min. X-ray examination showed that the magnets were in the appropriate position in 17 rats. The magnets were excreted in 9.47 ± 1.62 days after surgery. The gross and microscopic examination of the specimen showed that the anastomoses were patent and the mucosa at the anastomotic was smooth. The mean bursting pressure of the anastomosis was 136.94 ± 6.79 mmHg.

Conclusion

It is feasible to perform gastroenteric anastomosis through natural orifices by MCT.

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Funding

This work was supported by the Innovation Capability Support Plan of Shaanxi Province (Grant No. 2020KJXX-022) and the Key Research & Development Program-Social Development of Shaanxi Province (Grant No. 2021SF-163).

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Author notes

  1. Miaomiao Zhang and Yixing Li have contributed equally to this work and are co-first author.

Authors and Affiliations

  1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an, 710061, Shaanxi, People’s Republic of China

    Miaomiao Zhang, Min Pan, Shuqin Xu, Yingfeng An, Yi Lyu & Xiaopeng Yan

  2. National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an, 710061, Shaanxi, People’s Republic of China

    Miaomiao Zhang, Shuqin Xu, Yingfeng An, Aihua Shi, Yi Lyu & Xiaopeng Yan

  3. Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an, 710061, Shaanxi, People’s Republic of China

    Yixing Li

  4. Qide College, Xi’an Jiaotong University, No. 76 West Yanta Road, Xi’an, 710061, Shaanxi, People’s Republic of China

    Jingci Gai & Hanzhi Zhang

  5. Shaanxi Provincial Centre for Disease Control and Prevention, No. 3 Jiandong Street, Xi’an, 710054, Shaanxi, People’s Republic of China

    Yingfeng An

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  1. Miaomiao Zhang
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  3. Min Pan
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Corresponding authors

Correspondence to Yi Lyu or Xiaopeng Yan.

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Conflict of interest

During the conduct of this work, Miaomiao Zhang, Yixing Li, Min Pan, Shuqin Xu, Jingci Gai, Hanzhi Zhang, Yingfeng An, Aihua Shi, Yi Lyu and Xiaopeng Yan have no conflicts of interest or financial ties to disclose.

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Zhang, M., Li, Y., Pan, M. et al. Creation of gastroenteric anastomosis through natural orifice in rats by magnetic compression technique. Surg Endosc 36, 8170–8177 (2022). https://doi.org/10.1007/s00464-022-09257-z

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  • DOI: https://doi.org/10.1007/s00464-022-09257-z

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