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Original contribution: sleeve gastrectomy reduces soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in patients with morbid obesity

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Abstract

Background

Early diagnosis of subclinical cardiovascular disease (CVD) in patients with morbid obesity is important. We investigated the effects of sleeve gastrectomy (SG) on serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), oxidized LDL (oxLDL), and other metabolic and inflammatory parameters associated with atherosclerosis in patients with morbid obesity.

Methods

Body mass index (BMI) measurements and assays of metabolic and inflammatory markers were taken in patients in an SG surgery group and a healthy control group and compared at baseline and 12 months after SG. Correlations with changes in these parameters and variations in sLOX-1 were analyzed.

Results

Metabolic and inflammatory marker values in the surgery (n = 20) and control (n = 20) groups were significantly different at baseline (p < 0.001). The majority of surgery group biomarker levels significantly decreased with mean BMI loss (− 11.8 ± 9.0, p < 0.001) at 12 months, trending toward control group values. Baseline albumin level as well as percentage reductions in oxLDL and the cholesterol retention fraction (CRF) were found to be significantly correlated with percentage reduction in sLOX-1 at 12 months following SG.

Conclusion

Metabolic and inflammatory biomarkers elevated at baseline significantly decreased after SG weight loss. Weight loss induced by SG may limit endothelial damage by reducing levels of oxLDL and LOX-1 as assessed by sLOX-1. These findings suggest that sLOX-1 may function as a marker of atherosclerotic disease states in patients with morbid obesity and that metabolic/bariatric surgery can play a meaningful role in CVD prevention.

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Funding

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Authors and Affiliations

  1. Department of Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey

    Halit Eren Taskin, Ahmet Kocael, Pinar Kocael & Kagan Zengin

  2. Department of Surgery, Faculty of Medicine, Near East University, Nicosia, Turkey

    Muzaffer Al

  3. Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey

    Volkan Sozer

  4. Division of Scientific Research Writing, Medwrite Medical Communications, Maiden Rock, WI, USA

    J. N. Buchwald

  5. Statistical Analysis Division, McGlennon MotiMetrics, Maiden Rock, WI, USA

    T. W. McGlennon

  6. Department of Medical Biochemistry, Faculty of Medicine, İstanbul Atlas University, Istanbul, Turkey

    Hafize Uzun

Authors
  1. Halit Eren Taskin
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  2. Ahmet Kocael
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  4. Kagan Zengin
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  6. Volkan Sozer
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  7. J. N. Buchwald
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  9. Hafize Uzun
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Corresponding author

Correspondence to Halit Eren Taskin.

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Disclosures

Halit Eren Taskin, Ahmet Kocael, Pinar Kocael, Kagan Zengin, Muzaffer Al, Volkan Sozer, Jane Buchwald, Tim McGlennon, and Hafize Uzun have no conflicts of interest or financial ties to disclose.

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All procedures of the study are compliant with the ethical standards of Istanbul University, Cerrahpaşa Medical Faculty and were approved by its institutional review board.

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Informed consent was obtained from all study participants.

Research involving human and animal rights

The study was performed in accord with the ethical standards of the 1964 Declaration of Helsinki and subsequent amendments.

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Taskin, H.E., Kocael, A., Kocael, P. et al. Original contribution: sleeve gastrectomy reduces soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in patients with morbid obesity. Surg Endosc 36, 2643–2652 (2022). https://doi.org/10.1007/s00464-021-08989-8

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