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Should be a locally advanced colon cancer still considered a contraindication to laparoscopic resection?

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Abstract

Background

The role of elective laparoscopic resection (LR) for the treatment of locally advanced colon cancer (LACC) is unclear. Most studies have retrospectively investigated the outcomes of LR for pT4 cancers, while clinical T4 (cT4) cancers are excluded in the large randomized controlled trials comparing LR and open resection (OR). The aim of this study was to investigate the outcomes in patients undergoing elective LR for LACC.

Methods

A prospective single-institution database including consecutive patients undergoing elective LR for clinical LACC (high-risk T3 or T4 N0-2) between March 1996 and March 2017 was retrospectively reviewed. A multivariate analysis was performed to identify predictors of conversion to OR and risk factors for adverse oncologic outcomes.

Results

A total of 300 patients undergoing LR for LACC were included. A multi-visceral resection was needed in 17 (5.7%) patients. A total of 63 (21%) LRs were converted to OR, mainly due to suspected adjacent organ invasion (82.5%) or obesity (9.5%). Overall postoperative Clavien-Dindo 3–4 complication rate was 4.7%, with no significant differences between completed and converted LRs. Final pathology showed 18 (6%) pT2, 215 (71.7%) pT3, 54 (18%) pT4a, and 13 (4.3%) pT4b cancers. A R0 resection was achieved in 98.3% of patients. On multivariate analysis, tumor size ≥ 7 cm and tumor site (splenic flexure) were the independent risk factors for conversion to OR. A pT4 colon cancer and LNR of 0.25 or greater, but not conversion to OR, were independently associated with both poorer OS and DFS.

Conclusion(s)

Clinical LACC should not be considered a contraindication to LR itself. Bulky tumors ≥ 7 cm and splenic flexure cancers are at higher risk of conversion to OR; however, there is no increased postoperative morbidity or adverse oncologic outcomes in converted patients.

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Authors and Affiliations

  1. Department of Surgical Sciences, University of Torino, Corso A. M. Dogliotti, 14, 10126, Turin, Italy

    Laura Esposito, Marco E. Allaix, Bianca Galosi, Lorenzo Cinti, Alberto Arezzo, Carlo Alberto Ammirati & Mario Morino

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  1. Laura Esposito
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  2. Marco E. Allaix
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Correspondence to Marco E. Allaix.

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Drs. Laura Esposito, Marco Ettore Allaix, Bianca Galosi, Lorenzo Cinti, Alberto Arezzo, Carlo Alberto Ammirati, and Mario Morino have no conflicts of interest or financial ties to disclose.

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Esposito, L., Allaix, M.E., Galosi, B. et al. Should be a locally advanced colon cancer still considered a contraindication to laparoscopic resection?. Surg Endosc 36, 3039–3048 (2022). https://doi.org/10.1007/s00464-021-08600-0

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