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Optimal drainage of anastomosis stricture after living donor liver transplantation

Surgical Endoscopy volume 35, pages 6307–6317 (2021)Cite this article

A Correction to this article was published on 13 May 2021

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Abstract

Background

Endoscopic biliary stenting (EBS) with a fully covered, self-expandable metallic stent (FC-SEMS) and plastic stent (PS) is safe and efficient for biliary anastomotic strictures (ASs) after a deceased donor liver transplantation. Limited studies have investigated the use of FC-SEMSs for biliary strictures post-living donor liver transplantation (LDLT). We compared the resolution rate of biliary ASs post-LDLT and the 12-month recurrence rates post-stent removal between EBS with an FC-SEMS, PS, and percutaneous transhepatic biliary drainage (PTBD).

Methods

Patients with biliary ASs after an LDLT (mean age: 57.3 years, 76.1% men) hospitalized between 2014 and 2017 were enrolled. Endoscopic retrograde cholangiopancreatography (ERCP) was repeated every 3–4 months. Patients were followed-up for at least 1-year post-stent removal.

Results

Of the 75 patients enrolled, 16, 20, and 39 underwent EBS with an FC-SEMS, PS, and PTBD, respectively. Median follow-up period was 39.2 months. Fewer ERCP procedures were needed in the FC-SEMS group than in the PS group (median, 2 vs. 3; P = 0.20). Median stent indwelling periods were 4.7, 9.3, and 5.4 months in the FC-SEMS, PS, and PTBD groups, respectively (P = 0.006). The functional resolution rate was lower in the PS group (16/20) than in the FC-SEMS (16/16) or PTBD (39/39) group (P = 0.005). The radiologic resolution rate was higher in the FC-SEMS group (16/16) than in the PS group (14/20) (P = 0.07). The 12-month recurrence rates showed no significant differences (FC-SEMS, 4/16; PS, 3/16; PTBD, 6/39; P = 0.66). The rates of complications during treatment differed significantly between the groups (P = 0.04). Stent migration occurred in 1 (6.3%) and 5 (25.0%) patients in the FC-SEMS and PS groups, respectively (P = 0.59).

Conclusions

EBS with an FC-SEMS is comparable with EBS with a PS or PTBD in terms of biliary stricture resolution and 12-month recurrence rates. The use of FC-SEMSs is potentially effective and safe for biliary AS resolution after LDLT.

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Acknowledgements

Thanks to my friend Wookyong Kwon for encouraging me to write this article.

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Author notes

  1. Dong Jin Joo and Moon Jae Chung have contributed equally to this work.

  2. Min Je Sung and Jung Hyun Jo contributed equally to this work as primary authors.

Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea

    Min Je Sung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song & Moon Jae Chung

  2. Division of Gastroenterology, Department of Internal Medicine CHA Bundang Medical Center, CHA University, Gyeonggi-do, Republic of Korea

    Min Je Sung

  3. Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea

    Dong Jin Joo

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Correspondence to Dong Jin Joo or Moon Jae Chung.

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No authors have any financial relationships with any pharmaceutical or device company. Dr. Min Je Sung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Dong Jin Joo, and Moon Jae Chung have no conflicts of interest or financial ties to declare.

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Sung, M.J., Jo, J.H., Lee, H.S. et al. Optimal drainage of anastomosis stricture after living donor liver transplantation. Surg Endosc 35, 6307–6317 (2021). https://doi.org/10.1007/s00464-021-08456-4

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Keywords

  • Anastomotic biliary stricture
  • Endoscopic biliary stenting
  • Intra-ductal fully covered self-expanding metal stent
  • Plastic stent
  • Percutaneous transhepatic drainage