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Endoscopic versus surgical resection in the management of gastric schwannomas

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Abstract

Background and aims

Gastric schwannoma (GS) is not well clinically recognized and surgical resection (SR) remains the mainstay of treatment. Recently, endoscopic resection (ER) appears to be a safe and effective alternative. However, its comparative outcomes with SR is lacking. Our aim was to first compare clinical outcomes and costs between ER and SR in the management of GSs.

Methods

A total of 46 consecutive patients with GSs who underwent ER (n = 16) or SR (n = 30) in our large tertiary center between July 2007 and Oct 2018 were included. Clinicopathologic features, clinical outcomes, medical costs and follow-up were retrospectively reviewed and compared between two groups.

Results

Baseline characteristics are comparable except for a smaller tumor size in ER group (22.9 vs 41.0 mm, p = 0.002). Complete resection was achieved in 87.5% of patients with ER and 100% of patients with SR (p = 0.116). The ER group had a significant shorter operative time (91.6 vs 128.2 min), less blood loss (16.9 vs 62.7 mL) and lower operation cost (21,054.4 vs 30,843.4 RMB) than SR group (all p < 0.05). There was no significant difference in adverse events (12.5% vs 10%, p = 0.812) and length of postoperative hospital stay (8.3 vs 8.2 days, p = 0.945). During a long-term follow-up of mean 37.4 months (range 6–140 months), no residue, recurrence or metastasis was observed in both groups.

Conclusions

Compared with SR, ER has the similar safety and efficacy in the management of GSs, but contributes to a shorter operation time and lower medical costs. ER may be considered as the first-line treatment, especially for patients with GSs smaller than 30 mm.

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Acknowledgments

Thanks a lot for the work and help of all the physicians, surgeons, pathologists, technicians and nurses in the clinical management of these patients with gastric schwannoma.

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Author notes

  1. Ya-qi Zhai, Ning-li Chai, Wen-gang Zhang contribute to the paper equally, and are co-first authors.

Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Ya-qi Zhai, Ning-li Chai, Wen-gang Zhang, Hui-kai Li, Zhong-sheng Lu, Xiu-xue Feng, Sheng-zhen Liu & En-qiang Linghu

  2. Harvard Medical School, Boston, MA, 02115, USA

    Ya-qi Zhai

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  1. Ya-qi Zhai
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Correspondence to En-qiang Linghu.

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Drs Ya-qi Zhai, Ning-li Chai, Wen-gang Zhang, Hui-kai Li, Zhong-sheng Lu, Xiu-xue Feng, Sheng-zhen Liu, En-qiang Linghu have no conflicts of interest or financial ties to disclose.

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Zhai, Yq., Chai, Nl., Zhang, Wg. et al. Endoscopic versus surgical resection in the management of gastric schwannomas. Surg Endosc 35, 6132–6138 (2021). https://doi.org/10.1007/s00464-020-08108-z

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