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Endoscopic submucosal dissection involving the anal canal presents a risk factor for postoperative stricture

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Abstract

Background

Although postoperative strictures after endoscopic submucosal dissection (ESD) in the rectum are relatively rare, some rectal lesions require resection involving the anal canal, which is a narrow tract comprising squamous epithelium. To the best of our knowledge, no studies have investigated narrow anal canals when evaluating post-ESD strictures. This study aimed to evaluate the impact of resections involving the anal canal on postoperative stricture development.

Methods

Between April 2005 and October 2017, 707 rectal lesions were treated with ESD. We retrospectively investigated 102 lesions that required ≥ 75% circumferential resection. Risk factors for post-ESD stricture and, among patients with strictures, obstructive symptoms, and number of dilation therapies required were investigated.

Results

Post-ESD stricture occurred in 18 of 102 patients (17.6%). In the multivariate analysis, circumferential resection ≥ 90% and ESD involving the anal canal (ESD-IAC) were risk factors for postoperative strictures (P ≤ 0.0001 and 0.0115, respectively). Among the patients with strictures, obstructive symptoms were significantly related to anal strictures compared to rectal strictures (100% vs. 27.2%, P = 0.0041). Furthermore, the number of dilation therapies required was significantly greater among patients with anal strictures compared to those with rectal strictures (6.5 times vs. 2.7 times, P = 0.0263).

Conclusion

Not only circumferential resection ≥ 90% but also ESD-IAC was a significant risk factor for the stricture after rectal ESD. Furthermore, anal strictures were associated with a significantly higher frequency of obstructive symptoms and larger number of required dilation therapies than were rectal strictures.

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Authors and Affiliations

  1. Department of Gastroenterology, Kobe University Graduate School of Medicine School of Medicine, Kobe, Japan

    Tomoya Sako, Yoshiko Nakano, Shinwa Tanaka, Toshitatsu Takao, Yoshinori Morita, Eiji Umegaki & Yuzo Kodama

  2. Department of Endoscopy, Kobe University Hospital, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan

    Takashi Toyonaga

  3. Department of Endoscopy, Kishiwada Tokusyukai Hospital, Kishiwada, Japan

    Takashi Toyonaga, Shinichi Baba & Hiroshi Takihara

Authors
  1. Tomoya Sako
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  2. Takashi Toyonaga
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  3. Yoshiko Nakano
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  4. Shinwa Tanaka
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  5. Toshitatsu Takao
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  6. Shinichi Baba
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  8. Yoshinori Morita
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  10. Yuzo Kodama
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Corresponding author

Correspondence to Takashi Toyonaga.

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Conflict of interest

Tomoya Sako, Takashi Toyonaga, Yoshiko Nakano, Shinwa Tanaka, Toshitatsu Takao, Shinichi Baba, Hiroshi Takihara, Yoshinori Morita, Eiji Umegaki, and Yuzo Kodama have no conflicts of interest or financial ties to disclose.

Informed consent

Written informed consent was obtained from all participants before the ESD procedures and the study design was approved by the ethics committee at Kobe University Hospital and Kishiwada Tokushukai Hospital (180147). The study was conducted in accordance with principles of the Declaration of Helsinki.

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Sako, T., Toyonaga, T., Nakano, Y. et al. Endoscopic submucosal dissection involving the anal canal presents a risk factor for postoperative stricture. Surg Endosc 35, 1307–1316 (2021). https://doi.org/10.1007/s00464-020-07508-5

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  • DOI: https://doi.org/10.1007/s00464-020-07508-5

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