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SAGES TAVAC safety and efficacy analysis WATS3D (CDx Diagnostics, Suffern, NY)

  • SAGES TAVAC Analysis
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Abstract

Background

Wide-area transepithelial sampling of the esophagus with computer-assisted three-dimensional analysis (WATS3D, CDx Diagnostics, Suffern, NY) is an adjunctive technique to random biopsies for early detection of Barrett’s esophagus. The aim of the SAGES Technology and Value Assessment Committee aims is to evaluate the efficacy, value, and safety of WATS3D.

Methods

Clinical studies involving WATS3D were identified via a search of the PubMed/Medline databases (www.ncbi.nlm.nih.gov/pubmed) conducted in March of 2019 using search terms, such as wide-area transepithelial sampling, three-dimensional (3D) computer-assisted analysis, WATS-3D, Barrett’s esophagus and WATS-3D, Barrett’s esophagus and wide-area transepithelial sampling with three-dimensional computer-assisted analysis, Barrett’s esophagus, and emerging technology. Bibliographies of key references were searched for relevant studies not covered by the PubMed search. Case reports and small case series were excluded.

Results

No significant morbidity or mortality was reported within the literature associated with the WATS3D technology. WATS3D increases diagnostic yield by 38–150% for Barrett’s Esophagus, by 40–150% for Low Grade Dysplasia; and by 420% for High Grade Dysplasia; when compared to forceps biopsy alone. WATS3D technique has very high inter-observer agreement for the pathological diagnosis of non-dysplastic and dysplastic Barrett’s Esophagus. Increased detection of pre-malignant diseases of the esophagus by the adjunctive use of WATS3D supports screening and surveillance by the adjunctive use of WATS3D during upper endoscopy in appropriate patients.

Conclusion

Wide-area transepithelial sampling with three-dimensional computer-assisted analysis (WATS3D, CDx Diagnostics) is a safe and effective adjunct to forcep biopsies in the evaluation of Barrett’s Esophagus, Low Grade Dysplasia, and High Grade Dysplasia.

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Acknowledgements

SAGES Technology and Value Assessment Committee: Sharona Ross MD, Co-Chair, David Renton, MD, Co-Chair. SAGES Flexible Endoscopy Committee: Eric Pauli MD, Chair, Ryan Juza MD, Member. SAGES Foregut Task Force: Leena Khaitan MD, Chair, Marina Kurian MD, Co-Chair. SAGES Advocacy and Health Policy Committee: Ross Goldberg MD, Chair, John Roth MD, Co-Chair, Don Selzer MD, Member.

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Authors and Affiliations

  1. Division of Bariatric, Foregut, and Advanced GI Surgery, Stony Brook Medicine, 101 Nicolle Road, Stony Brook, NY, 11794, USA

    Salvatore Docimo Jr.

  2. Department of Surgery, University of Massachusetts Medical School/Baystate, Springfield, MA, USA

    Mazen Al-Mansour

  3. VIP Surg, Las Vegas, NV, USA

    Shawn Tsuda

Authors
  1. Salvatore Docimo Jr.
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  2. Mazen Al-Mansour
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  3. Shawn Tsuda
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Correspondence to Salvatore Docimo Jr..

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Disclosures

Salvatore Docimo: Consulting or received general payments from Boston Scientific Corporation, W. L. Gore & Associates, Inc., Gore, Intuitive Surgical Inc. Mazen Al-Mansour: General payments from Intuitive Surgical, Inc. Shawn Tsuda: Consulting, education honoraria, research support, and general payments from Allergan Inc., Intuitive Surgical Inc., Endo Pharmaceuticals Inc., and Covidien LP.

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Docimo, S., Al-Mansour, M. & Tsuda, S. SAGES TAVAC safety and efficacy analysis WATS3D (CDx Diagnostics, Suffern, NY). Surg Endosc 34, 3743–3747 (2020). https://doi.org/10.1007/s00464-020-07503-w

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  • DOI: https://doi.org/10.1007/s00464-020-07503-w

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