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Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model

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Abstract

Background

An intragastric satiety-inducing device (ISD) (Full Sense Device; Baker, Foote, Kemmeter, Walburn, LLC, Grand Rapids, MI) is a novel weight-loss device, which may induce satiety by applying continuous pressure on the gastric cardia. This study investigated the effect of the ISD on food intake and body weight gain in a rodent model.

Methods

Thirty-two male Sprague–Dawley rats (weight, 250–300 g) were randomly divided into four groups of eight individuals. Single-disk (SD) and double-disk (DD) group animals underwent peroral placement of a single- or double-disk ISD, respectively, under fluoroscopic guidance. The ISD comprised a 4 mm × 1.5 cm nitinol stent placed in the lower esophagus and one (single-disk) or two (double-disk) 2.5-cm-diameter star-shaped nitinol disks placed in the gastric fundus. Esophageal stent (ES) and sham-operated (SO) group animals underwent peroral placement of the ES part of the ISD and a sham operation, respectively.

Results

Food intake was significantly different among the four groups over the 4-week study period (P < 0.001); food intake was significantly lower in the SD and DD groups than in the SO group (P = 0.016 and P = 0.002, respectively) but was not significantly different between the SD and DD groups (P > 0.999) and between the ES and SO groups (P = 0.677). Body weight was significantly different among the four groups by the end of the study period (P < 0.001); body weight was significantly lower in the DD group than in the SD, ES, and SO groups (P = 0.010, P < 0.001, and P < 0.001, respectively) and in the SD group than in the SO group (P = 0.001), but it was not significantly different between the ES and SO groups (P = 0.344).

Conclusion

ISD reduced food intake and suppressed body weight gain in a rodent model.

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Abbreviations

BMI:

Body mass index

ISD:

Intragastric satiety-inducing device

SD:

Single-disk

DD:

Double-disk

ES:

Esophageal stent

SO:

Sham-operated

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Funding

This study was supported by a grant from the National Key R&D Program of China (grant No. 2017YFC0107800 to X.L.) and a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant No. HI18C0631 to H.Y.J.).

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Author notes

  1. Yingen Luo and Xiaowu Zhang have contributed equally to this work and are co-first authors.

Authors and Affiliations

  1. Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China

    Yingen Luo, Xiaowu Zhang, Jiaywei Tsauo, He Zhao, Jingui Li, Tao Gong, Peng Song & Xiao Li

  2. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea

    Hwoon-Yong Jung

  3. Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138-736, Republic of Korea

    Ho-Young Song

Authors
  1. Yingen Luo
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  2. Xiaowu Zhang
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Corresponding author

Correspondence to Jiaywei Tsauo.

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Disclosures

Yingen Luo, Xiaowu Zhang, Jiaywei Tsauo, Hwoon-Yong Jung, Ho-Young Song, He Zhao, Jingui Li, Tao Gong, Peng Song, and Xiao Li have no conflicts of interest or financial ties to disclose.

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All applicable institutional and/or national guidelines for the care and use of animals were followed.

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Luo, Y., Zhang, X., Tsauo, J. et al. Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model. Surg Endosc 35, 1052–1057 (2021). https://doi.org/10.1007/s00464-020-07467-x

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