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Effects of steroid use for stenosis prevention after wide endoscopic submucosal dissection for gastric neoplasm

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Abstract

Background

Stenosis is a troublesome complication after wide endoscopic submucosal dissection (ESD). As steroids are known to prevent post-ESD esophageal stenosis, this study aimed to clarify the gastric effects.

Methods

This was a retrospective single-institution study. Between September 2002 and June 2015, 132 patients with a post-ESD mucosal defect exceeding three-fourths of the circumference were identified. Among them, 107 patients who did not undergo additional surgery for non-curative resection were reviewed. Steroid treatment (local injection and/or systemic) for stenosis prevention was administered to 28 patients within 10 days after ESD (steroid group). The incidence of stenosis and course of therapeutic endoscopic balloon dilation (EBD) were analyzed between the steroid and non-steroid group.

Results

Stenosis occurred in 31% (33/107) of patients. Full circumferential defect and defect extending to the pyloric ring were significantly related with stenosis. The proportion of patients with a full circumferential defect was relatively higher in the steroid group (14%) compared to the non-steroid group (5%) (p = 0.111). There was no significant relationship between the incidence of stenosis and the use of steroids (steroid group 39%, non-steroid group 28%, p = 0.260). However, the interval from ESD to stenosis was significantly delayed among steroid-treated patients with a near-circumferential to three-fourth mucosal defect (p = 0.001) and among patients with ESD in the lower stomach (p = 0.002). The number of therapeutic EBDs and treatment duration did not differ significantly between the groups. Steroid treatment did not increase the incidence of ESD- and EBD-related complications.

Conclusion

Despite the retardation of the occurrence of stenosis in some subgroups, early steroid treatment did not a show a significant effect on stenosis prevention after wide gastric ESD. Further evaluation is needed to determine the dose and timing of steroid treatment for stenosis after wide gastric ESD.

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Authors and Affiliations

  1. Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Suntogun, Nagaizumi, Shizuoka, 411-8777, Japan

    Yoshihiro Kishida, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Noboru Kawata, Masao Yoshida, Sayo Ito, Kenichiro Imai, Hirotoshi Ishiwatari, Kinichi Hotta, Hiroyuki Matsubayashi & Hiroyuki Ono

Authors
  1. Yoshihiro Kishida
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  2. Naomi Kakushima
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  3. Kohei Takizawa
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  4. Masaki Tanaka
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  5. Noboru Kawata
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  6. Masao Yoshida
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  7. Sayo Ito
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  8. Kenichiro Imai
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  9. Hirotoshi Ishiwatari
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  10. Kinichi Hotta
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  11. Hiroyuki Matsubayashi
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Correspondence to Yoshihiro Kishida.

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Drs. Yoshihiro Kishida, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Noboru Kawata, Masao Yoshida, Sayo Ito, Kenichiro Imai, Hirotoshi Ishiwatari, Kinichi Hotta, Hiroyuki Matsubayashi, and Hiroyuki Ono have no conflict of interest or interests of financial ties to disclose.

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Kishida, Y., Kakushima, N., Takizawa, K. et al. Effects of steroid use for stenosis prevention after wide endoscopic submucosal dissection for gastric neoplasm. Surg Endosc 32, 751–759 (2018). https://doi.org/10.1007/s00464-017-5732-5

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  • DOI: https://doi.org/10.1007/s00464-017-5732-5

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