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Laparoscopic versus open distal pancreatectomy for nonfunctioning pancreatic neuroendocrine tumors: a large single-center study

Surgical Endoscopy volume 32, pages 443–449 (2018)Cite this article

Abstract

Background

Pancreatic neuroendocrine tumors (PNETs) account for 1–2% of all pancreatic neoplasms. Nonfunctioning PNETs (NF-PNETs) account for 60–90% of all PNETs. Laparoscopic distal pancreatectomy (LDP) is becoming the treatment of choice for benign lesions in the body and tail of the pancreas. However, LDP has not yet been widely accepted as the gold standard for NF-PNETs. The purpose of this study is to evaluate the clinical and oncologic outcomes after laparoscopic versus open distal pancreatectomy (ODP) for NF-PNETs.

Methods

Between April 1995 and September 2016, 94 patients with NF-PNETs underwent open or laparoscopic distal pancreatectomy at Samsung Medical Center. Patients were divided into two groups: those who underwent LDP and those who underwent ODP. Both groups were compared in terms of clinical and oncologic variables.

Results

LDP patients had a significantly shorter hospital stay compared with ODP patients, amounting to a mean difference of 2 days (p < 0.001). Overall complication rates did not differ significantly between the ODP and LDP groups (p = 0.379). The 3-year overall survival rates in the ODP and LDP groups were 93.7 and 100%, respectively (p = 0.069).

Conclusions

In this study, LDP for NF-PNETs had similar oncologic outcomes compared with ODP. In addition, LDP was associated with a shorter hospital stay compared with ODP. Therefore, LDP is a safe and effective procedure for patients with NF-PNETs. A multicenter study and a randomized controlled trial are needed to better assess the clinical and oncologic outcomes.

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Affiliations

  1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, South Korea

    Sang Hyup Han, In Woong Han, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Sunjong Han & Yung hun You

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  1. Sang Hyup Han
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Sang Hyup Han, In Woong Han, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Sunjong Han, and Yung hun You have no conflicts of interest or financial ties to disclose.

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Cite this article

Han, S.H., Han, I.W., Heo, J.S. et al. Laparoscopic versus open distal pancreatectomy for nonfunctioning pancreatic neuroendocrine tumors: a large single-center study. Surg Endosc 32, 443–449 (2018). https://doi.org/10.1007/s00464-017-5702-y

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  • DOI: https://doi.org/10.1007/s00464-017-5702-y

Keywords

  • Laparoscopy
  • Distal pancreatectomy
  • Pancreatic neuroendocrine tumor