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Surgical Endoscopy

, Volume 31, Issue 10, pp 3801–3810 | Cite as

SAGES Technology and Value Assessment Committee safety and effectiveness analysis on immunofluorescence in the operating room for biliary visualization and perfusion assessment

  • Bryan J. Sandler
  • Danny Sherwinter
  • Lucian Panait
  • Richard Parent
  • Jennifer Schwartz
  • David RentonEmail author
SAGES Committee Report

The ability to assess tissue perfusion and identify vital structures in the operating room in order to potentially decrease complication rates remains a key goal for surgeons. The introduction of immunofluorescence utilizing indocyanine green intraoperatively to evaluate areas such as an anastomosis, a free flap, biliary anatomy, or lymphatics has the possibility of decreasing postoperative complications by addressing identification and perfusion concerns at the time of surgery.

The use of laser-induced immunofluorescence using indocyanine green relies on similar principles as fluorescein technique, which was first proposed in 1942. Fluorescein angiography was initially used to evaluate vascularity of the eye and skin. Fluorescein angiography did not become clinically significant, however, due to difficulties with the tracer. Indocyanine green, a second-generation tracer, was developed in order to overcome the limitations of fluorescein. Indocyanine green (ICG) is a water-soluble...

Notes

Compliance with ethical standards

Disclosures

Bryan J Sandler reports Consulting Fee for ValenTx, Inc, and Honoraria for Gore and Bard-Davol; Danny Sherwinter reports IP Rights for Novadaq and Research for Navidea; Lucian Panait, Richard Parent, Jennifer Schwartz, and David Renton have no conflict of interest or financial ties to disclose.

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Copyright information

© Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) 2017

Authors and Affiliations

  • Bryan J. Sandler
    • 1
  • Danny Sherwinter
    • 2
  • Lucian Panait
    • 3
  • Richard Parent
    • 4
  • Jennifer Schwartz
    • 5
  • David Renton
    • 6
    Email author
  1. 1.University of California San Diego HealthSan DiegoUSA
  2. 2.Maimonides Medical CenterBrooklynUSA
  3. 3.AtlantiCare Regional Medical CenterAtlantic CityUSA
  4. 4.St. Helena HospitalSt. HelenaUSA
  5. 5.Beth Israel Deaconess Medical CenterBostonUSA
  6. 6.Ohio State University Wexner Medical CenterColumbusUSA

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