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Patient satisfaction after endoscopic submucosal dissection under propofol-based sedation: a small premedication makes all the difference

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Abstract

Background

Ideal sedation for endoscopic submucosal dissection (ESD) aims to satisfy both the endoscopist and patient. However, previous studies show that a satisfactory procedure for the endoscopist does not equal higher patient satisfaction. This study attempted to find a sedation protocol that is able to increase patient satisfaction during propofol-based sedation by adding low-dose midazolam as premedication.

Methods

Seventy-two adult patients were randomly allocated to receive either 0.02 mg/kg midazolam (Midazolam Group) or placebo (Control Group) as premedication before ESD. Sedation was done by targeting Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) scale of 3 or 4 with continuous propofol infusion and bolus doses of fentanyl. Satisfaction scores of the endoscopists and patients, and whether the patient was willing to receive the same sedation method in the future was assessed. Interim analysis was done after enrollment of 50 % of patients.

Results

This study was prematurely terminated when interim analysis showed that patients willing to receive the same sedation method in the future were significantly lower in the Control Group compared to the Midazolam Group (P = 0.001). There was no difference in sedation time, procedure and recovery time, drug requirements and adverse events between the two groups. Endoscopist and overall patient satisfaction scores, patient pain scores and degree of recall were also similar between groups.

Conclusions

A small dose of midazolam given as premedication before propofol-based sedation is able to reduce patient reluctance to repeat the same procedure in the future, without affecting procedural performance, recovery time or endoscopist satisfaction.

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Acknowledgments

Funding was provided solely from departmental sources.

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Author notes

    Authors and Affiliations

    1. Department of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Korea

      Seokyung Shin, Sang Hun Park & Young Chul Yoo

    2. Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Korea

      Chan Hyuk Park

    3. Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Institute of Gastroenterology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Korea

      Hyun Ju Kim & Sang Kil Lee

    Authors
    1. Seokyung Shin
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    2. Chan Hyuk Park
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    3. Hyun Ju Kim
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    4. Sang Hun Park
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    5. Sang Kil Lee
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    Correspondence to Sang Kil Lee or Young Chul Yoo.

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    Disclosures

    Drs Seokyung Shin, Chan Hyuk Park, Hyun Ju Kim, Sang Hun Park, Sang Kil Lee and Young Chul Yoo have no conflicts of interest or financial ties to disclose.

    Additional information

    Seokyung Shin and Chan Hyuk Park contributed equally to this work as first authors. Sang Kil Lee and Young Chul Yoo contributed equally to this work as corresponding authors. This paper has two co-first authors and two co-corresponding authors.

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    Shin, S., Park, C.H., Kim, H.J. et al. Patient satisfaction after endoscopic submucosal dissection under propofol-based sedation: a small premedication makes all the difference. Surg Endosc 31, 2636–2644 (2017). https://doi.org/10.1007/s00464-016-5276-0

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    • DOI: https://doi.org/10.1007/s00464-016-5276-0

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