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Evaluating long-term attachment of a novel endoclip in porcine stomachs: a prospective study of initial deployment success and clip retention rates at different regions of the stomachs

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Abstract

Background and aims

Through-the-scope endoscopic clips are widely used. Several designs of endoscopic clips are marked for different applications. However, no prior reports have been published to aid in comparing success rates of clip deployment and the retention rates at different regions of the stomachs. The aims of the article were to compare success rates of clip deployment and the retention rates at different regions of the stomachs with a novel endoclip.

Methods

Upper endoscope was inserted into the stomach of five pigs under general anesthesia. In all animals, three regions of the stomachs (gastric fundus, gastric body, and gastric antrum) were chosen as the sites of clip application. Two clips of a novel type were placed along the same gastric site at a distance of 0.5–1 cm from each other. Animals had weekly endoscopies to quantitate clip retention.

Results

Success rates of clip deployment were 70 % for gastric fundus, 100 % for gastric body, and 100 % for gastric antrum. Clip retention rates were significantly higher with gastric body than with gastric fundus or gastric antrum at 1–8 weeks.

Conclusions

(1) For the clip device, it seems that it is difficult for the clip deployment in gastric fundus (70 %) than that in the gastric body or gastric antrum (100 %), but there is no statistical significance (χ 2 test, p = 0.21). (2) Clips used in the gastric body were retained significantly longer than that in the gastric fundus or gastric antrum. (3) The novel clips were safe, and no complications such as bleeding or weight loss were noted.

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Acknowledgments

The authors thank De-Rong Leng, Chris Li, and Chun-Jun Liu from Micro-Tech Co Ltd, Nanjing, China, for their efforts related to the coordination and technical training of the use of the novel clips.

Disclosures

Bo Yan, Rui-Hua Shi, Ya-Dong Feng, and Zhen-Hai Di have no conflicts of interest or financial ties to disclose

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Authors and Affiliations

  1. Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, Jiangsu, China

    Bo Yan & Zhen-Hai Di

  2. The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China

    Rui-Hua Shi & Ya-Dong Feng

Authors
  1. Bo Yan
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  2. Rui-Hua Shi
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  3. Ya-Dong Feng
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  4. Zhen-Hai Di
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Corresponding author

Correspondence to Zhen-Hai Di.

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Yan, B., Shi, RH., Feng, YD. et al. Evaluating long-term attachment of a novel endoclip in porcine stomachs: a prospective study of initial deployment success and clip retention rates at different regions of the stomachs. Surg Endosc 30, 1100–1106 (2016). https://doi.org/10.1007/s00464-015-4305-8

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  • DOI: https://doi.org/10.1007/s00464-015-4305-8

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