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Imaging visceral adhesion to polymeric mesh using pneumoperitoneal-MRI in an experimental rat model

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Abstract

Background

Intraperitoneal mesh implantation is often associated with formation of adhesion to the mesh. This experimental study examines the potential of minimally invasive pneumoperitoneal-MRI to assess these adhesions in a preclinical context.

Methods

Uncoated polyethylene terephthalate meshes were placed intraperitoneally in rats, in regard to the caecum previously scraped to promote petechial bleeding and subsequent adhesions. Examinations were performed 2-weeks post mesh implantation using a rodent dedicated high field MRI. Respiratory-triggered T2-weighted images were acquired prior to and after intraperitoneal injection of ~8–10 mL gas to induce a mechanical stress on the abdominal wall.

Results

Adhesions are occasionally seen in sham-operated rats as opposed to rats receiving polyethylene terephthalate meshes. On high-resolution images, meshes can be detected due to their characteristic net shape. However, evidence of adherence is only found if intraperitoneal gas injection is performed, when a ~1-cm elevation of the abdominal wall is observed. When adherence occurs between the mesh and the caecum, the latter remains in contact with the wall. Looser adherences between visceral tissue and meshes are also observed.

Conclusions

T2-weighted pneumoperitoneal-MRI is a powerful tool for assessing adherence after intraperitoneal mesh implantation. According to the mini-invasive procedure adopted here, this approach may allow a temporal follow-up of adherence fate.

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Acknowledgments

The authors are grateful to Dr. O. Lefranc (Covidien, Trevoux, France) for the generous gift of the polyethylene terephthalate textile and Ms. A. Mourlan (Service Commun d’Animalerie Hospitalo-Universitaire, Université d’Angers) for peri-operative animal care. Dr. M.S.N Carpenter post-edited the English style.

Disclosures

F. Franconi, J. Roux, C. Lefebvre-Lacoeuille and L. Lemaire have no conflicts of interest or financial ties to disclose.

Author information

Authors and Affiliations

  1. PRIMEX-CIFAB, Université d’Angers, LUNAM Université, IRIS-IBS, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France

    Florence Franconi

  2. Service Commun d’Animalerie Hospitalo-Universitaire, Université d’Angers, LUNAM Université, Pavillon Ollivier, UFR Sciences médicales, rue Haute de reculée, 49045, Angers Cedex 1, France

    Jérome Roux

  3. INSERM UMR-S 1066, Université d’Angers, LUNAM Université, IRIS-IBS, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France

    Céline Lefebvre-Lacoeuille & Laurent Lemaire

  4. Service de Chirurgie Gynécologique - CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France

    Céline Lefebvre-Lacoeuille

Authors
  1. Florence Franconi
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  2. Jérome Roux
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  3. Céline Lefebvre-Lacoeuille
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  4. Laurent Lemaire
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Corresponding author

Correspondence to Laurent Lemaire.

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Franconi, F., Roux, J., Lefebvre-Lacoeuille, C. et al. Imaging visceral adhesion to polymeric mesh using pneumoperitoneal-MRI in an experimental rat model. Surg Endosc 29, 1567–1573 (2015). https://doi.org/10.1007/s00464-014-3843-9

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  • DOI: https://doi.org/10.1007/s00464-014-3843-9

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