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Iatrogenic ureteral injury in colorectal cancer surgery: a nationwide study comparing laparoscopic and open approaches

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Abstract

Background

Iatrogenic ureteral injury is a rare complication in colorectal surgery. We aimed to investigate the risk of ureteral injury among patients with colorectal cancer operated on with curative intent in Denmark with laparoscopic and open technique.

Method

The study was based on the Danish National Colorectal Cancer database (DCCG) and included patients treated with intended curative resection for colorectal cancer between 2005 and 2011. From the DCCG database, we extracted data on intraoperative urinary tract injuries. To identify urinary tract injuries not recognized at the time of surgery but within 30 days after surgery, we cross-linked data with the National Patient Registry. All ureteral injuries were confirmed by medical record review. Data were analyzed separately for colon and rectal cancer.

Results

A total of 18,474 patients had a resection for colorectal cancer. Eighty-two ureteral injuries were related to colorectal surgery. The rate of ureteral injuries in the entire cohort was 0.44 %, with 37 (0.59 %) injuries in the laparoscopic group (n = 6,291) and 45 (0.37 %) injuries in the open group (n = 12,183), (P = 0.03). No difference in ureteral injury was found in relation to surgical approach in colon cancer patients. In rectum cancer patients (n = 5,959), the laparoscopic approach was used in 1,899 patients, and 19 (1.00 %) had ureteral injuries, whereas 17 (0.42 %) of 4,060 patients who underwent an open resection had a ureteral injury. In multivariate analysis adjusted for age, gender, ASA score, BMI, tumor stage, preoperative chemo-radiation, calendar year, and specialty of the surgeon, the laparoscopic approach was associated with an increased risk of ureteral injury, OR = 2.67; 95 % CI 1.26–5.65.

Conclusion

In this nationwide study laparoscopic surgery for rectal cancer with curative intent was associated with a significantly increased risk of iatrogenic ureteral injury compared to open surgery.

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Acknowledgments

The Danish Colorectal Cancer Group is thanked for Granting access to the database. Dr. Steffen Høgskilde provided technical assistance by extracting data from the DCCG database and the National Patient Registry. Statistical analysis was done in cooperation with Leif Spange Mortensen, M.Sc.

Disclosures

Drs. Peter Andersen, Lars Maagaard Andersen, and Lene H. Iversen have no conflict of interest or financial ties to disclose.

Funding

Lene Iversen was supported by Grants from the Danish Council for Independent Research/Medical Sciences (10-081843).

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Authors and Affiliations

  1. Department of Surgery P, Aarhus University Hospital, Tage-Hansens Gade 2, 8000, Aarhus C, Denmark

    Peter Andersen & Lene H. Iversen

  2. Department of Surgery, Regional Hospital Randers, Randers, Denmark

    Lars Maagaard Andersen

Authors
  1. Peter Andersen
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  2. Lars Maagaard Andersen
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  3. Lene H. Iversen
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Correspondence to Peter Andersen.

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ON BEHALF OF DCCG.

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Andersen, P., Andersen, L.M. & Iversen, L.H. Iatrogenic ureteral injury in colorectal cancer surgery: a nationwide study comparing laparoscopic and open approaches. Surg Endosc 29, 1406–1412 (2015). https://doi.org/10.1007/s00464-014-3814-1

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  • DOI: https://doi.org/10.1007/s00464-014-3814-1

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