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Laparoscopic resection for large gastric gastrointestinal stromal tumor (GIST): intermediate follow-up results

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Abstract

Background

Laparoscopic wedge resection has become a widely accepted treatment for small gastrointestinal stromal tumor (GIST) of the stomach. However, its feasibility as treatment for large gastric GIST is not known. In this retrospective study, the perioperative and oncologic outcomes of laparoscopic wedge resection for gastric GIST (5–8 cm) were reviewed.

Methods

Between November 2002 and December 2012, a total of 39 patients with primary gastric GIST sized 5–8 cm underwent surgery at a tertiary care center, including 18 patients who underwent laparoscopic wedge resection of the stomach (Lap group) and 21 patients who underwent open wedge resection of the stomach (Open group). Clinicopathological parameters were reviewed and compared between the groups.

Results

The demographics including age, gender, and body weight were similar between groups. The operative outcomes including blood loss, hospital stay, and surgical complications were also similar, except that operative time was longer in the Lap group (146.6 ± 50.2 vs. 113.3 ± 42.9 min in the Open group, p = 0.03). There was no tumor rupture, conversion of procedures, or major surgical morbidity in either group. The overall median follow-up time was 3.6 years (1.0–11.1). Only one patient in the Lap group had liver metastasis (4 months postoperatively). This patient remains alive 5 years later under imatinib treatment. One patient in the Open group and three patients in the Lap group have died of GIST-unrelated diseases.

Conclusions

Laparoscopic wedge resection of the stomach for primary gastric GIST (5–8 cm) appears to be safe and feasible, with operative and oncological outcomes comparable to those of the open method.

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Disclosures

Dr. Chih-Yang Hsiao, Dr. Ching-Yao Yang, Dr. I-Rue Lai, Prof. Chiung-Nien Chen, and Prof. Ming-Tsan Lin have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan

    Chih-Yang Hsiao, Ching-Yao Yang, I-Rue Lai, Chiung-Nien Chen & Ming-Tsan Lin

  2. Department of Anatomy and Cell Biology, Medical College, National Taiwan University, Taipei, Taiwan

    I-Rue Lai

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  1. Chih-Yang Hsiao
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  2. Ching-Yao Yang
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  3. I-Rue Lai
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  4. Chiung-Nien Chen
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Correspondence to I-Rue Lai.

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Hsiao, CY., Yang, CY., Lai, IR. et al. Laparoscopic resection for large gastric gastrointestinal stromal tumor (GIST): intermediate follow-up results. Surg Endosc 29, 868–873 (2015). https://doi.org/10.1007/s00464-014-3742-0

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  • DOI: https://doi.org/10.1007/s00464-014-3742-0

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