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Biomedical nanostructured coating for minimally invasive surgery devices applications: characterization, cell cytotoxicity evaluation and an animal study in rat

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Abstract

Background

Thermal injury and tissue sticking, which influence wound remodeling, are major concerns in electrosurgery. In this study, the effect of lateral thermal injury caused by different electrosurgical electrodes on hepatic remodeling was investigated.

Methods

A monopolar electrosurgical unit equipped with untreated stainless steel (SS) and chromium nitride coated stainless steel (CrN-SS) electrodes was used to create lesions on the liver lobes of adult rats. Animals were sacrificed for evaluations at 0, 3, 7, and 28 days postoperatively.

Results

CrN-SS needles generated lower levels of sticking tissue, and the thermographs showed that recorded highest temperature in liver tissue from the CrN-SS needle group was significantly lower than in the SS needle group. The total injury area of livers treated with CrN-SS needles was significantly lower than livers treated with SS needles at each time point. Moreover, the CrN-SS needles caused a relatively smaller area of lateral thermal injury, a smaller area of fibrotic tissue, and a faster process of hepatic remodeling in rat liver than the SS needles. Immunofluorescence staining and Western blot analysis showed that rats treated with CrN-SS needles expressed lower levels of NF-κB and caspase-3 postoperatively.

Conclusions

This study reveals that the plating of electrodes with a CrN film is an efficient method for improving the performance of electrosurgical units and should benefit wound remodeling. However, more tests must be performed to confirm these promising findings in human patients.

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Acknowledgments

The authors thank the Center of Excellence for Clinical Trial and Research in Neurology and Neurosurgery, Taipei Medical University-Wan Fang Hospital for financially supporting this research under contract No. DOH102-TD-B-111-003, supported partly by the Department of Health, Executive Yuan, Taiwan under contract No. DOH102-TD-N-111-001.

Disclosures

Keng-Liang Ou, Jan-Show Chu, Hossein Hosseinkhani, Jeng-Fong Chiou, and Chih-Hua Yu have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Graduate Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan

    Keng-Liang Ou

  2. Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, 110, Taiwan

    Keng-Liang Ou, Jan-Show Chu & Chih-Hua Yu

  3. Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, 110, Taiwan

    Keng-Liang Ou & Chih-Hua Yu

  4. Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Taipei, 235, Taiwan

    Keng-Liang Ou

  5. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan

    Jan-Show Chu

  6. Department of Pathology, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan

    Jan-Show Chu

  7. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan

    Hossein Hosseinkhani

  8. Department of Radiation Oncology, School of Medicine, Taipei Medical University, Taipei, 110, Taiwan

    Jeng-Fong Chiou

  9. Cancer Center and Department of Radiation Oncology, Taipei Medical University and Hospital, Taipei, 110, Taiwan

    Jeng-Fong Chiou

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  1. Keng-Liang Ou
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  2. Jan-Show Chu
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  3. Hossein Hosseinkhani
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  4. Jeng-Fong Chiou
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  5. Chih-Hua Yu
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Corresponding author

Correspondence to Jeng-Fong Chiou.

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Ou, KL., Chu, JS., Hosseinkhani, H. et al. Biomedical nanostructured coating for minimally invasive surgery devices applications: characterization, cell cytotoxicity evaluation and an animal study in rat. Surg Endosc 28, 2174–2188 (2014). https://doi.org/10.1007/s00464-014-3450-9

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  • DOI: https://doi.org/10.1007/s00464-014-3450-9

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