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Minimally invasive surgery for serosa-positive gastric cancer (pT4a) in patients with preoperative diagnosis of cancer without serosal invasion

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Abstract

Background

Although surgeons normally use minimally invasive surgery (MIS) for patients with early gastric cancer, in Korea and Japan the procedure is also indicated for serosa-negative tumors. Serosal invasion is regarded to be a potential risk factor for peritoneal dissemination as a result of the effect of pneumoperitoneum and tumor manipulation during the operation. We compared operative outcomes between MIS and conventional open surgery for serosa-involved advanced gastric cancer patients who had a preoperative diagnosis of cancer without serosal invasion.

Methods

A total of 61 patients (39 patients treated by MIS and 22 by open surgery) treated between 2003 and 2009 who were first diagnosed preoperatively as serosa negative on the basis of computed tomography, endoscopy, and endoscopic ultrasound but then diagnosed as serosa positive upon final pathology were studied. We retrospectively compared recurrence and survival between the two treatment groups.

Results

Clinicopathologic characteristics, clinical stage, extent of surgery, and short-term operative outcome did not differ between the groups. 5-year overall survival (73.5 vs. 67.5 %, p = 0.518, respectively) and disease-free survival (67.8 vs. 54.2 %, p = 0.296, respectively) were comparable between the MIS and open surgery groups. There were recurrences in 12 patients in the MIS group and 11 patients in the open surgery group, with a median follow-up period of 64 months. Recurrence patterns did not differ between the groups; moreover, MIS did not increase peritoneal recurrences compared to open surgery (42.0 vs. 54.5 %, p = 0.537, respectively). In multivariate analyses, the type of surgery was not an independent prognostic factor.

Conclusions

Similar survival and recurrence patterns were observed in advanced gastric cancer patients preoperatively diagnosed as serosa negative who were treated either by MIS or open surgery. MIS may be safely applied in patients with serosa-positive tumors.

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Disclosures

T. Son, W. J. Hyung, J. H. Lee, Y. M. Kim, and S. H. Noh have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, Eulji General Hospital, Eulji University School of Medicine, Seoul, Republic of Korea

    T. Son

  2. Department of Surgery, Graduate School, Yonsei University College of Medicine, Seoul, Republic of Korea

    T. Son, J. H. Lee & Y. M. Kim

  3. Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

    W. J. Hyung, J. H. Lee, Y. M. Kim & S. H. Noh

  4. Robot and Minimally Invasive Surgery Center, Yonsei University College of Medicine, Seoul, Republic of Korea

    W. J. Hyung

  5. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea

    W. J. Hyung & S. H. Noh

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Correspondence to W. J. Hyung.

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Son, T., Hyung, W.J., Lee, J.H. et al. Minimally invasive surgery for serosa-positive gastric cancer (pT4a) in patients with preoperative diagnosis of cancer without serosal invasion. Surg Endosc 28, 866–874 (2014). https://doi.org/10.1007/s00464-013-3236-5

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  • DOI: https://doi.org/10.1007/s00464-013-3236-5

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