Skip to main content
Log in

Influence of fibrin sealant in preventing postoperative seroma and normalizing the abdominal wall after laparoscopic repair of ventral hernia

  • Published:
Surgical Endoscopy Aims and scope Submit manuscript



Seroma after laparoscopic ventral hernia repair (LVHR) has been related to certain complications of the technique, such as recurrences and postoperative pain. The aim of this study was to assess whether percutaneous application of fibrin sealant in the hernia sac after LVHR reduces the incidence and volume of the postoperative seroma, and to analyze whether the percentage of patients achieving complete normalization of the abdominal wall increases.


Prospective and comparative study. Patients were distributed into 2 control–case groups. Group 1 comprised patients submitted to LVHR using the double crown technique and a compressing bandage as the only method for prevent seroma. Group 2 comprised patients admitted to LVHR using the same technique together with percutaneous injection of fibrin sealant in the sac, and later applying the same bandage. Patients were examined clinically and radiologically at 7 days, 1 month, and 3 months after surgery.


Twenty-five patients were included in each group. There were significant differences in the incidence of seroma by the day 7 after surgery (92 % in group 1 vs. 64 % in group 2, p = 0.017) and by 1 month (72 % in group 1 vs. 28 % in group 2, p = 0.002). The difference was also significant regarding the achievement of normalization of the abdominal wall by day 7 (24 % in group 1 vs. 52 % in group 2, p = 0.041) and by month 1 (64 % in group 1 vs. 88 % in group 2, p = 0.047) after operation. Volume of seroma was larger among patients of group 1 after the week (p = 0.002) and 1 month after operation (p = 0.001).


Fibrin sealant application after LVHR reduces the incidence and volume of the seroma 7 days and 1 month after surgery. The treated patients obtain a larger normalization of the abdominal wall 1 week and 1 month after the operation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others


  1. Heniford BT, Park A, Ramshaw BJ, Voeller G (2003) Laparoscopic repair of ventral hernias nine years’ experience with 850 consecutive hernias. Ann Surg 238:391–399

    PubMed  Google Scholar 

  2. Sajid MS, Bokhari SA, Mallick AS, Cheek E, Baig MK (2009) Laparoscopic versus open repair of incisional/ventral hernia: a meta-analysis. Am J Surg 197:64–72

    Article  PubMed  Google Scholar 

  3. Susmallian S, Gewurtz G, Ezri T, Charuzi I (2001) Seroma alter laparoscopic repair of hernia with PFE match: is it really a complicaction? Hernia 5:139–141

    Article  PubMed  CAS  Google Scholar 

  4. Tsimoyiannis EC, Siakas P, Glantzounis G, Koulas S, Mavridou P, Gossios KI (2001) Seroma in laparoscopic ventral hernioplasty. Surg Laparosc Endosc Percutan Tech 11(5):317–321

    Article  PubMed  CAS  Google Scholar 

  5. Chelala E, Thoma M, Tatete B, Lemye AC, Dessily M, Alle JL (2007) The suturing concept for laparoscopic mesh fixation in ventral and incisional hernia repair: mid-term analysis of 400 cases. Surg Endosc 21(3):391–395

    Article  PubMed  CAS  Google Scholar 

  6. Toosie K, Gallego K, Stabile BE, Schaber B, French S, de Virgilio C (2000) Fibrin glue reduces intra-abdominal adhesions to synthetic mesh in a rat ventral hernia model. Am Surg 66:41–45

    PubMed  CAS  Google Scholar 

  7. Morales-Conde S, Cadet H, Cano A, Bustos M, Martín J, Morales-Mendez S (2005) Laparoscopic ventral hernia repair without sutures—double crown technique: our experience after 140 cases with a mean follow-up of 40 months. Int Surg 90(3 Suppl):S56–S62

    PubMed  Google Scholar 

  8. Morales-Conde S (2012) A new classification for seroma after laparoscopic ventral hernia repair. Hernia 16(3):261–267

    Article  PubMed  CAS  Google Scholar 

  9. Parker HH 3rd, Nottingham JM, Bynoe RP, Yost MJ (2002) Laparoscopic repair of large incisional hernias. Am Surg 68(6):530–533

    PubMed  Google Scholar 

  10. Heniford BT, Park A, Ramshaw BJ, Voeller G (2000) Laparoscopic ventral and incisional hernia repair in 407 patients. J Am Coll Surg 190(6):645–650

    Article  PubMed  CAS  Google Scholar 

  11. Eid GM, Prince JM, Mattar SG, Hamad G, Ikrammudin S, Schauer PR (2003) Medium-term follow-up confirms the safety and durability of laparoscopic ventral hernia repair with PTFE. Surgery 134(4):599–603

    Article  PubMed  Google Scholar 

  12. Chowbey PK, Sharma A, Khullar R, Mann V, Baijal M, Vashistha A (2000) Laparoscopic ventral hernia repair. J Laparoendosc Adv Surg Tech A 10(2):79–84

    Article  PubMed  CAS  Google Scholar 

  13. Wassenaar E, Schoenmaeckers E, Raymakers J, van der Palen J, Rakic S (2010) Mesh-fixation method and pain and quality of life after laparoscopic ventral or incisional hernia repair: a randomized trial of three fixation techniques. Surg Endosc 24(6):1296–1302

    Article  PubMed  Google Scholar 

Download references


D. Aurelio Cayuela performed the statistical data analysis. The following radiologists took part in this study by performing and analyzing the CT scans, which were essential for the success of the present study: Drs. Carlos Gutierrez, Blanca Vargas, and Antonio Talegon.


  S. Morales-Conde, G. Suárez-Artacho, M. Socas, and A. Barranco have no conflicts of interest or financial ties to disclose.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gonzalo Suárez-Artacho.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morales-Conde, S., Suárez-Artacho, G., Socas, M. et al. Influence of fibrin sealant in preventing postoperative seroma and normalizing the abdominal wall after laparoscopic repair of ventral hernia. Surg Endosc 27, 3214–3219 (2013).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: