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Endoscopic balloon dilatation for benign fibrotic strictures after curative nonsurgical treatment for esophageal cancer

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Abstract

Background

Endoscopic balloon dilatation (EBD) is performed to treat strictures after esophagectomy. However, little is known about using EBD for benign strictures that occur after nonsurgical treatments for esophageal cancer such as chemoradiotherapy (CRT) or endoscopic mucosal resection (EMR). The aim of this study was to evaluate the safety and efficacy of EBD for benign strictures after nonsurgical treatment compared with those after surgery.

Methods

We identified 823 patients with esophageal cancer who completed definitive treatments between 2004 and 2007. Of these patients, 122 were enrolled in our study, including 60 who had surgery and 62 who did not have surgery (32 CRT, 30 EMR). The indication criteria for EBD were complaint of dysphagia and the inability to pass a conventional endoscope due to benign stricture. We retrospectively analyzed the safety and efficacy of EBD, and the measured outcomes were treatment success rate, time to treatment success, and refractory stricture rate.

Results

Perforation occurred in 3 (0.3 %) of 1,077 EBD sessions, with no bleeding. Efficacy was evaluated in 110 of the 122 patients. While the treatment success rate was over 90 % in both the surgery and the nonsurgery group, there was a significant difference in the median time to treatment success between both groups (2.3 vs. 5.6 months, p = 0.02: log-rank test). There was a significant difference in the median time to treatment success between CRT and surgery groups (7.0 months, p = 0.01), with no significant difference in the EMR group (4.4 months, p = 0.85). A significant difference in the refractory stricture rate was evident between the nonsurgery group (75 %) and the surgery group (45 %, p < 0.01).

Conclusion

EBD for stricture after nonsurgical treatment of esophageal cancer was safe and effective. However, patients with benign strictures after nonsurgical treatment required significantly longer time to recover from dysphasia compared to those after surgery.

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Disclosure

Y. Yoda, T. Yano, K. Kaneko, S. Tsuruta, Y. Oono, T. Kojima, K. Minashi, H. Ikematsu, and A. Ohtsu have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwanoha 6-5-1, Kashiwa, Chiba, 277-8577, Japan

    Yusuke Yoda, Tomonori Yano, Kazuhiro Kaneko, Shinya Tsuruta, Yasuhiro Oono, Takashi Kojima, Keiko Minashi, Hiroaki Ikematsu & Atsushi Ohtsu

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  1. Yusuke Yoda
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  2. Tomonori Yano
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  3. Kazuhiro Kaneko
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  4. Shinya Tsuruta
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  5. Yasuhiro Oono
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  6. Takashi Kojima
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  7. Keiko Minashi
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  8. Hiroaki Ikematsu
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  9. Atsushi Ohtsu
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Correspondence to Tomonori Yano.

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Yoda, Y., Yano, T., Kaneko, K. et al. Endoscopic balloon dilatation for benign fibrotic strictures after curative nonsurgical treatment for esophageal cancer. Surg Endosc 26, 2877–2883 (2012). https://doi.org/10.1007/s00464-012-2273-9

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  • DOI: https://doi.org/10.1007/s00464-012-2273-9

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