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Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model

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Abstract

Introduction

The use of staplers in gastrointestinal surgery is widespread, especially in advanced laparoscopic procedures. Staple line reinforcement with a buttress reduces bleeding and associated complications through a combination of factors. The intrinsic hemostatic properties of buttress materials have not been examined. This study examined the intrinsic hemostatic properties of two different types of material used in buttressing in an accepted hemostasis model that does not involve stapling or its effects by compression.

Materials

An acellular collagen buttress (Veritas®) and a synthetic polymer buttress (Duet™) were compared to two commonly used hemostatic agents, Syvek® and Surgicel®, with gauze as control.

Methods

In a swine capsular stripping hemostasis model, a 1 × 1 cm section of spleen capsule was removed and used as a source of bleeding, with one patch of material tested per bleeding site. A total of 51 wounds were created in five pigs (each patch n = 10, control n = 11). Hemostatic efficacy was assessed by quantitating the number of applications and total time needed for bleeding to stop.

Results

The mean time needed for hemostasis for Syvek® and Veritas® patches was significantly less than gauze, Duet™ and Surgicel® (4.02, 4.51 vs. 8.97, 9.22, and 10.30 min respectively; p < 0.05). The Syvek® and Veritas® patches required significantly fewer applications than gauze, Duet™ and Surgicel® (1.7, 2.2 vs. 4.1, 4.6, and 4.9 respectively; p < 0.01).

Conclusions

The intrinsic hemostatic properties of different buttressing materials vary widely. In this study, a collagen buttress was significantly better at promoting hemostasis than the synthetic buttress material in a nonstapling model. This could be another factor to consider when choosing a buttress for staple line reinforcement.

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Disclosures

David Spector and Scott Shikora have received grant support for research from Synovis Life Technologies. Scot Shikora is part of a scientific advisory board and a consultant for Synovis Life Technologies. Tracy Konobeck and Dan Mooradian work in the Research and Development Department of Synovis Life Technologies. Zvi Perry has no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, Tufts Medical Center, 800 Washington St, Box # 437, Boston, MA, 02111, USA

    David Spector & Scott Shikora

  2. Department of Surgery, Soroka University Medical Center, Beer Sheva, Israel

    Zvi Perry

  3. Synovis Life Technologies, St. Paul, MN, USA

    Tracy Konobeck & Daniel Mooradian

Authors
  1. David Spector
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  2. Zvi Perry
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  3. Tracy Konobeck
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  4. Daniel Mooradian
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  5. Scott Shikora
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Correspondence to David Spector.

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Spector, D., Perry, Z., Konobeck, T. et al. Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model. Surg Endosc 25, 1148–1152 (2011). https://doi.org/10.1007/s00464-010-1331-4

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  • DOI: https://doi.org/10.1007/s00464-010-1331-4

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