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Endoscopic mucosal resection for gastroesophageal cancer in a U.K. population. Long-term follow-up of a consecutive series

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Abstract

Background

Endoscopic mucosal resection (EMR) of early gastric and esophageal tumors is effective and avoids the morbidity and mortality of surgery. We report the long-term results of a consecutive series of 93 endoscopic resections, during a 7-year period, in a U.K. population.

Methods

Eighty-eight patients with 93 lesions were included. EMR was performed for 64 and 29 malignant and benign lesions, respectively. Patients with malignant disease were subgrouped into “high risk” or “low risk” for recurrence.

Results

Of the 35 lesions in the low-risk group, local control was achieved in 31; 29 after 1 EMR session. Two had residual invasive carcinoma, one had treatment ceased due to pancreatic cancer, and one patient did not attend follow-up. Of the 29 lesions in the high-risk group, local control was achieved in 15; 13 after 1 EMR session. Median follow-up was 53 months. Cancer specific survival for the 45 invasive cancers (T1m and T1sm) was 93%; three patients died from their disease.

Conclusions

This study has shown for the first time in a U.K. population that EMR is effective in controlling disease in patients with local high grade dysplasia (HGD) and early invasive carcinoma, with no mortality and low morbidity.

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Disclosures

Dr. Andrew B.C. Crumley, Dr. James J. Going, Dr. Kerryanne McEwan, Ms. Margaret McKernan, Dr. Jo-Etienne Abela, Dr. Christopher J. Shearer, Dr. Adrian J. Stanley, and Dr. Robert C. Stuart have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK

    Andrew B. C. Crumley, Margaret McKernan, Jo-Etienne Abela, Christopher J. Shearer & Robert C. Stuart

  2. University Department of Pathology, Royal Infirmary, Glasgow, G31 2ER, UK

    James J. Going & Kerryanne McEwan

  3. University Department of Medicine, Royal Infirmary, Glasgow, G31 2ER, UK

    Adrian J. Stanley

Authors
  1. Andrew B. C. Crumley
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  2. James J. Going
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Correspondence to Andrew B. C. Crumley.

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Crumley, A.B.C., Going, J.J., McEwan, K. et al. Endoscopic mucosal resection for gastroesophageal cancer in a U.K. population. Long-term follow-up of a consecutive series. Surg Endosc 25, 543–548 (2011). https://doi.org/10.1007/s00464-010-1213-9

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  • DOI: https://doi.org/10.1007/s00464-010-1213-9

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