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RETRACTED ARTICLE: Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy

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This article was retracted on 30 April 2013

Abstract

The common and distressing complications of postoperative nausea and vomiting (PONV) are the main concern of 40–70% of patients undergoing laparoscopic cholecystectomy (LC). The first step in preventing PONV after LC is to reduce the risk factors involving patient characteristics, surgical procedure, anesthetic technique, and postoperative care. Particularly, the use of propofol-based anesthesia can reduce the incidence of PONV after LC. Second, prophylactic antiemetics including antihistamines (dimenhydrinate), phenothiazines (perphenazine), butyrophenones (droperidol), benzamides (metoclopramide), dexamethasone, and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) are available for preventing PONV after LC. Third, antiemetic therapy combined with a serotonin receptor antagonist (ondansetron, granisetron) and droperidol or dexamethasone is highly effective in the prevention of PONV after LC. Fourth, acupressure at the P6 point is a nonpharmacologic technique that is as effective as ondansetron for preventing PONV after LC. Knowledge regarding the risk factors for PONV and antiemetics is needed for the management of PONV after LC.

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References

  1. Cunningham AJ (1994) Laparoscopic surgery: anesthetic implications. Surg Endsc 8:1272–1284

    CAS  Google Scholar 

  2. Cunningham AJ, Brull SJ (1993) Laparoscopic cholecystectomy: anesthetic implications. Anesth Analg 76:1120–1133

    Article  PubMed  CAS  Google Scholar 

  3. Rose DK, Choen MM, Soutter DI (1992) Laparoscopic cholecystectomy: the anaesthetist’s point of view. Can J Anaesth 39:809–815

    Article  PubMed  CAS  Google Scholar 

  4. Naguib M, el Bakry AK, Khoshim MH, Channa AB, el Gammal M, el Gammal K, Elhattab YS, Attia M, Jaroudi R, Saddique A (1996) Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo. Can J Anaesth 43:226–231

    Article  PubMed  CAS  Google Scholar 

  5. Jokela R, Koivuranta M (1999) Tropisetron or droperidol in the prevention of postoperative nausea and vomiting: a comparative, randomised, double-blind study in women undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Scand 43:645–650

    Article  PubMed  CAS  Google Scholar 

  6. Wang JJ, Ho ST, Liu YH, Lee SC, Liu YC, Liano YC, Ho CM (1999) Dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy. Br J Anaesth 83:772–775

    Article  PubMed  CAS  Google Scholar 

  7. Watcha MF, White PF (1992) Postoperative nausea and vomiting: its etiology, treatment, and prevention. Anesthesiology 77:162–170

    Article  PubMed  CAS  Google Scholar 

  8. Kovac AL (2000) Prevention and treatment of postoperative nausea and vomiting. Drugs 59:213–243

    Article  PubMed  CAS  Google Scholar 

  9. Borison HL, Wang SC (1953) Physiology and pharmacology of vomiting. Pharm Rev 5:192–230

    Google Scholar 

  10. Wang SC, Borrison HL (1950) The vomiting center: a critical experimental analysis. Arch Neuro Psych 63:928–941

    Article  CAS  Google Scholar 

  11. Apfel CC, Grein CA, Haubitz I, Goepfert C, Usadel J, Sefrin P, Roewer N (1998) A risk score to predict the probability of postoperative vomiting in adults. Acta Anaesthesiol Scand 42:495–501

    Article  PubMed  CAS  Google Scholar 

  12. Sinclair DR, Chung F, Mezei G (1999) Can postoperative nausea and vomiting be predicted? Anesthesiology 91:109–118

    Article  PubMed  CAS  Google Scholar 

  13. Apfel CC, Laara E, Koivuranta M, Greim CA, Roewer N (1999) A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 91:693–700

    Article  PubMed  CAS  Google Scholar 

  14. Beattie WS, Lindblad T, Buckley DN, Forrest JB (1991) The incidence of postoperative nausea and vomiting in women undergoing laparoscopy is influenced by the day of menstrual cycle. Can J Anaesth 38:298–302

    Article  PubMed  CAS  Google Scholar 

  15. Smessaert A, Schehr CA, Artusio JF Jr (1959) Nausea and vomiting in the immediate postoperative period. JAMA 170:2072–2076

    Article  CAS  Google Scholar 

  16. Hough MB, Sweeney BP (1998) The influence of smoking on postoperative nausea and vomiting. Anaesthesia 53:932–933

    Article  PubMed  CAS  Google Scholar 

  17. Sweeny BP (2002) Why does smoking protect against PONV? Br J Anaesth 89:810–813

    Article  Google Scholar 

  18. Iitomi T, Toriumi S, Kondo A, Akazawa T, Nakahara T (1995) Incidence of nausea and vomiting after cholecystectomy performed via laparotomy or laparoscopy (Japanese). Masui 44:1727–1731

    Google Scholar 

  19. Jenkins JC, Lahay D (1971) Central mechanisms of vomiting related to catecholamine response: anaesthetic implication. Can Anaesth Soc 18:434–441

    Article  CAS  Google Scholar 

  20. Perreault L, Normandin N, Plamondon L, Blain R, Rousseau P, Girard M, Forget G (1982) Middle ear pressure variations during nitrous oxide and oxygen anaesthesia. Can Anaesth Soc J 29:428–434

    Article  PubMed  CAS  Google Scholar 

  21. Hartung J (1996) Twenty-four of twenty-seven studies show a greater incidence of emesis with nitrous oxide than alternative anesthetics. Anesth Analg 83:114–116

    PubMed  CAS  Google Scholar 

  22. Taylor E, Feinstein R, White PF, Soper N (1992) Anesthesia for laparoscopic cholecystectomy: is nitrous oxide contraindicated? Anesthesiology 76:541–543

    Article  PubMed  CAS  Google Scholar 

  23. Sneyd JR, Carr A, Byrom WD, Bilski AJT (1998) A mata-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents. Eur J Anaesthesiol 15:433–445

    PubMed  CAS  Google Scholar 

  24. Klockgether-Radke A, Piorek V, Crozier T, Kettler D (1996) Nausea and vomiting after laparoscopic surgery: a comparison of propofol and vomiting after laparoscopic surgery: a comparison of propofol and thiopentone/halothane anaesthesia. Eur J Anaesthesiol 13:3–9

    Article  PubMed  CAS  Google Scholar 

  25. Borgeat A, Wilder-Smith OHG, Saiah M, Rifat K (1992) Subhypnotic doses of propofol possess direct antiemetic properties. Anesth Analg 74:539–541

    Article  PubMed  CAS  Google Scholar 

  26. Ostman PL, Faure E, Glosten B, Kemen M, Robert MK, Bedwell S (1990) Is the antiemetic effect of the emulsion of propofol due to the lipid emulsion? Anesth Analg 71:536–540

    PubMed  CAS  Google Scholar 

  27. Bonica JJ, Crepps W, Monk B, Bennett B (1958) Postoperative nausea, retching and vomiting: evaluation of cyclizine (marezine) suppositories for treatment. Anesthesiology 19:432–540

    Article  Google Scholar 

  28. Kranke P, Morin AM, Roewer N, Eberhart HJ (2002) Dimenhydrinate for prophylaxis of postoperative nausea and vomiting: a mata-analysis of randomized controlled trial. Acta Anaesthesiol Scand 46:238–244

    Article  PubMed  CAS  Google Scholar 

  29. Eberhart LH, Seeling W, Bopp TI, Morin AM, Georgieff M (1999) Dimenhydrinate for prevention of postoperative nausea and vomiting in female inpatients. Eur J Anaesthesiol 16:284–289

    PubMed  CAS  Google Scholar 

  30. Kothari SN, Boyd WC, Bottcher ML, Lambert PJ (2000) Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran): a randomized, prospective trial inpatients undergoing laparoscopic cholecystectomy. Surg Endosc 14:926–929

    Article  PubMed  CAS  Google Scholar 

  31. Stwart DJ (1990) Cancer therapy, vomiting and antiemetics. Can J Physiol Pharmacol 68:304–313

    Article  Google Scholar 

  32. Steinbrook RA, Gosnell JL, Freiberger D (1998) Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perpherazine, droperidol plus ondansetron, and droperidol plus metoclopramide. J Clin Anesth 10:494–498

    Article  PubMed  CAS  Google Scholar 

  33. Loeser EA, Bennet G, Stanley TH, Marchin R (1979) Comparison of droperidol, haloperidol, and prochlorperazine as postoperative antiemetics. Can Anaesth Soc J 26:125–127

    Article  PubMed  CAS  Google Scholar 

  34. Helmy SA (1999) Prophylactic antiemetic efficacy of ondansetron in laparoscopic cholecystectomy under total intravenous anaesthesia: a randomized, double-blind comparison with droperidol, metoclopramide, and placebo. Anaesthesia 54:266–271

    Article  PubMed  CAS  Google Scholar 

  35. McCormick C (2002) FDA alert: current FDA report on droperidol status and basis for “black box” warning. Am Soc Anesthesiol Newslett 66:19–20

    Google Scholar 

  36. Habib AS, Gan TJ (2003) Food and drug administration black box warning on the perioperative use of droperidol: a review of the cases. Anesth Analg 96:1377–1379

    Article  PubMed  Google Scholar 

  37. Harrington RA, Hamilton CW, Brogden RN, Linkwwich JA, Romankiewicz JA, Heel RC (1983) Metoclopramide: an update review of its pharmacological properties and clinical use. Drugs 25:451–494

    Article  PubMed  CAS  Google Scholar 

  38. Wilson EB, Bass CS, Abrameit W, Roberson R, Smith RW (2001) Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy. Am J Surg 181:138–141

    Article  PubMed  CAS  Google Scholar 

  39. Quaynor H, Raeder JC (2002) Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. Acta Anaesthesiol Scand 46:109–113

    PubMed  CAS  Google Scholar 

  40. Henzi I, Walder B, Tramer MR (2000) Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 99:186–194

    Article  Google Scholar 

  41. Schimmer BP, Parler KL (2001) Adrenocorticotropic hormone: adrenocortical steroids and their synthetic analogs: inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG (eds) Goodman and Gilmann’s the pharmacological basis of therapeutics, 10th edn. McGraw-Hill, New York, pp 1649–1677

    Google Scholar 

  42. Feo CV, Sortini D, Ragazzi R, DePalma M, Liboni A (2006) Randomized clinical trial of the effect of preoperative dexamethasone on nausea and vomiting after laparoscopic cholecystectomy. Br J Surg 93:295–299

    Article  PubMed  CAS  Google Scholar 

  43. Wang JJ, Ho ST, Uen YH, Lin MT, Chen KT, Huang JC, Tzeng JI (2002) Small-dose dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy: a comparison of tropisetron with saline. Anesth Analg 95:229–232

    Article  PubMed  CAS  Google Scholar 

  44. Cabrera JC, Matute E, Escolano F, Castillo J, Santiveri X, Castano J (1997) Efficacy of ondansetron in the prevention of nausea and vomiting after laparoscopic cholecystectomy (in Spanish). Rev Esp Anesthesiol Reanim 44:36–38

    CAS  Google Scholar 

  45. Liberman MA, Howe S, Lane M (2000) Ondansetron versus placebo for prophylaxis of nausea and vomiting in patients undergoing ambulatory laparoscopic cholecystectomy. Am J Surg 179:60–62

    Article  PubMed  CAS  Google Scholar 

  46. Grover VK, Mathew PJ, Hegde H (2009) Efficacy of orally disintegrating ondansetron in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomised, double-blind placebo controlled study. Anaesthesia 64:595–600

    Article  PubMed  CAS  Google Scholar 

  47. Fujii Y, Saitoh Y, Tanaka H, Toyooka H (1998) Effective dose of granisetron in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecyectomy. Eur J Anaesthesiol 15:287–291

    PubMed  CAS  Google Scholar 

  48. Fujii Y, Tanaka H, Kawasaki T (2001) Prophylaxis with oral granisetron for the prevention of nausea and vomiting after laparoscopic cholecystectomy: a prospective randomized study. Arch Surg 136:101–104

    Article  PubMed  CAS  Google Scholar 

  49. Piper SN, Suttner SW, Rohm KD, Maleck WH, Larbig E (2002) Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecyetectomy. Can J Anesthesiol 49:1021–1028

    Article  Google Scholar 

  50. Walker JB (2001) Efficacy of single-dose intravenous dolasetron versus ondansetron in the prevention of postoperative nausea and vomiting. Clin Ther 23:932–938

    Article  PubMed  CAS  Google Scholar 

  51. Fujii Y, Uemura A, Tanaka H (2002) Prophylaxis of nausea and vomiting after laparoscopic cholecystectomy with ramosetron: randomised controlled trial. Eur J Surg 168:583–586

    Article  PubMed  CAS  Google Scholar 

  52. Bunce KT, Tyers MB (1992) The role of 5-HT in postoperative nausea and vomiting. Br J Anaesth 69:60S–62S

    Article  PubMed  CAS  Google Scholar 

  53. Rowbotham DJ (1992) Current management of postoperative nausea and vomiting. Br J Anaesth 69:46S–59S

    Article  PubMed  CAS  Google Scholar 

  54. Smith DB, Newlands ES, Rustin GJ, Begent RH, Howells N, McQuade B, Bagshawe KD (1991) Comparison of ondansetron and ondansetron plus dexamethasone as antiemetic prophylaxis during cisplatin-containing chemotherapy. Lancet 338:487–490

    Article  PubMed  CAS  Google Scholar 

  55. Youngs S (1981) Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis. Br J Pharmacol 74:695–700

    Article  Google Scholar 

  56. Frederikson M, Mursti T, Furst C, Steineck G, Borjeson S, Wikblom M (1992) Nausea in cancer chemotherapy is inversely related to urinary cortisol excretion. Br J Cancer 65:779–780

    Article  Google Scholar 

  57. Sager S (1991) The current role of antiemetic drugs in oncology: a recent revolution in patient symptom control. Cancer Treat Rev 18:95–135

    Article  Google Scholar 

  58. Award IT, Murphy D, Stack D, Swanton BJ, Meeke RI, Shorten GD (2002) A comparison of effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy. J Clin Anesth 14:481–485

    Article  Google Scholar 

  59. Fujii Y, Saitoh Y, Tanaka H, Toyooka H (1998) Prophylactic antiemetic therapy with granisetron–droperidol combination in patients undergoing laparoscopic cholecystectomy. Can J Anaesth 45:541–544

    Article  PubMed  CAS  Google Scholar 

  60. Elhakim M, Nafie M, Mahmoud K, Atef A (2002) Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy. Can J Anesth 49:922–926

    Article  PubMed  Google Scholar 

  61. Fujii Y, Saitoh Y, Tanaka H, Toyooka H (2000) Granisetron/dexamethasone combination for the prevention of postoperative nausea and vomiting after laparoscopic cholecyetectomy. Eur J Anaesthesiol 17:64–68

    PubMed  CAS  Google Scholar 

  62. Lee A, Done ML (1999) The use of nonpharmacologic technique to prevent postoperative nausea and vomiting: a meta-analysis. Anesth Analg 88:1362–1369

    PubMed  CAS  Google Scholar 

  63. Agarwal A, Bose N, Gaur A, Singh U, Gupta MK, Singh D (2002) Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecytectomy. Can J Anesth 49:554–560

    Article  PubMed  Google Scholar 

  64. Frey UH, Funk M, Lohleim C, Peters J (2009) Effect of P6 acustimulation on postoperative nausea and vomiting in patients undergoing a laparoscopic cholecystectomy. Acta Anaesthesiol Scand 53:1341–1347

    Article  PubMed  CAS  Google Scholar 

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Disclosure

Yoshitaka Fujii has no conflicts of interests or financial ties to disclose.

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  1. First Department of Anesthesiology, Toho University School of Medicine, 6-11-1, Ohmori-Nish, Ohta-ku, Tokyo, 143-8541, Japan

    Yoshitaka Fujii

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Correspondence to Yoshitaka Fujii.

Additional information

A retraction note to this article is available at http://dx.doi.org/10.1007/s00464-013-2966-8.

The Editors-in-Chief and the Editorial Director of Clinical Medicine would like to retract this article because the study on which the article was based was conducted without ethics committee approval.

An erratum to this article is available at http://dx.doi.org/10.1007/s00464-013-2966-8.

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Fujii, Y. RETRACTED ARTICLE: Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Surg Endosc 25, 691–695 (2011). https://doi.org/10.1007/s00464-010-1193-9

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