Surgical Endoscopy

, Volume 24, Issue 5, pp 1099–1103 | Cite as

Positive end-expiratory pressure in pressure-controlled ventilation improves ventilatory and oxygenation parameters during laparoscopic cholecystectomy

  • Ji Young Kim
  • Cheung Soo Shin
  • Hong Soon Kim
  • Wol Sun Jung
  • Hyun Jeong KwakEmail author



During laparoscopy, pneumoperitoneum may result in intraoperative atelectasis, which impairs normal gas exchange. This study investigated whether positive end-expiratory pressure (PEEP) of 5 cmH2O in pressure-controlled ventilation (PCV) mode can improve ventilatory and oxygenation parameters during pneumoperitoneum.


Thirty patients, aged 18–65 years, undergoing laparoscopic cholecystectomy were randomly allocated to the ZEEP (PEEP = 0 cmH2O) or PEEP (PEEP = 5 cmH2O) group. PCV was started after induction of anesthesia. Apart from PEEP level, all other ventilator settings were identical for both groups. Peak airway pressure was set at induction and reset after pneumoperitoneum to deliver tidal volume of 8 ml/kg in both groups. Hemodynamic, ventilatory, and oxygenation parameters were measured after induction of anesthesia (T1) and 30 min after pneumoperitoneum (T2).


Oxygenation index (PaO2/FiO2) was significantly higher in the PEEP group than in the ZEEP group at T2 (P = 0.031). In both groups, dynamic compliance significantly decreased over 40 min from T1 to T2. There were no significant differences in hemodynamics between the two groups during the study period.


Application of PEEP of 5 cmH2O should be considered in PCV during laparoscopic surgeries to decrease intraoperative atelectasis caused by pneumoperitoneum to improve gas exchange and oxygenation.


Pneumoperitoneum Pressure-controlled ventilation Cholecystectomy Oxygenation 



Drs. Ji Young Kim, Cheung Soo Shin, Hong Soon Kim, Wol Sun Jung, and Hyun Jeong Kwak have no conflicts of interest or financial ties to disclose.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ji Young Kim
    • 1
  • Cheung Soo Shin
    • 1
  • Hong Soon Kim
    • 2
  • Wol Sun Jung
    • 2
  • Hyun Jeong Kwak
    • 2
    Email author
  1. 1.Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research InstituteYonsei University College of MedicineSeoulKorea
  2. 2.Department of Anesthesiology and Pain MedicineGachon University of Medicine and Science Gil Medical CenterIncheonKorea

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