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Symptomatic gallstones after sleeve gastrectomy

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Abstract

Background

Cholelithiasis is a common complication after bariatric surgery. Pure restrictive procedures such as sleeve gastrectomy and gastric banding theoretically should result in less gallstone formation because the food continues to follow the normal gastrointestinal transit, maintaining the enteric–endocrine reflex intact. To the authors’ knowledge, the literature has no studies that analyze the incidence of gallstone formation after sleeve gastrectomy. This study aimed to compare the rates of symptomatic gallstones between laparoscopic Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG).

Methods

A retrospective chart review of patients who underwent laparoscopic RYGBP and SG between 2004 and 2006 was performed. The patients with previous cholecystectomy, known gallstones with or without concomitant cholecystectomy, and previous weight-reduction operations were excluded from the analysis. The outcome measures were the numbers of patients who had experienced symptomatic and complicated gallstones. Using Cox regression analysis, comparisons was made between the patients with laparoscopic RYGBP (group A) and those with laparoscopic SG (group B).

Results

Groups A excluded 174 (26%) of 670 patients, and group B excluded 27 (34.2%) of 79 patients. The patients in group A had a significantly higher preoperative body mass index (BMI) than those in group B. Additionally, more group A than group B patients had a BMI exceeding 45 and more than a 25% loss of original weight. No significant difference in the development of symptomatic (8.7% vs. 3.8%; p = 0.296) or complicated (1.8% vs. 1.9%; p = 0.956) gallstones was noted between the two groups

Conclusions

There was no significant difference in symptomatic or complicated gallstone disease between the patients treated with laparoscopic SG and those treated with laparoscopic RYGBP. Routine prophylactic cholecystectomy should not be recommended for weight reduction during laparoscopic SG.

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References

  1. Villegas L, Schneider B, Provost D, Chang C, Scott D, Sims T, Hill L, Hynan L, Jones D (2004) Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg 14:206–211

    Article  PubMed  Google Scholar 

  2. Brandao I, de Oliveira C, Adami Chaim E, da Silva BB (2003) Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg 13:625–628

    Article  Google Scholar 

  3. Shiffman ML, Sugerman HJ, Kellum JM, Brewer WH, Moore EW (1991) Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol 86:1000–1005

    CAS  PubMed  Google Scholar 

  4. Dhabuwala A, Cannan RJ, Stubbs RS (2000) Improvement in comorbidities following weight loss from gastric bypass surgery. Obes Surg 10:428–435

    Article  CAS  PubMed  Google Scholar 

  5. Portenier DD, Grant JP, Blackwood HS, Pryor A, McMahon RL, Demaria E (2007) Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis 3:476–479

    Article  PubMed  Google Scholar 

  6. Bennion LJ, Grundy SM (1992) Risk factors for the development of cholelithiasis in man (second of two parts). N Engl J Med 307:798–800

    Google Scholar 

  7. Diehl AK (1991) Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 20:1–19

    CAS  PubMed  Google Scholar 

  8. Jorgensen T (1989) Gallstones in a Danish population: relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus. Gut 30:528–534

    Article  CAS  PubMed  Google Scholar 

  9. Mason EE (2002) Gallbladder management in obesity surgery. Obes Surg 12:222–229

    Article  PubMed  Google Scholar 

  10. Heaton KW, Braddon FEM, Mountford RA, Hughes AO, Emmett PM (1991) Symptomatic and silent gallstones in the community. Gut 32:316–320

    Article  CAS  PubMed  Google Scholar 

  11. Stampfer MJ, Maclure KM, Colditz GA, Manson JE, Willett WC (1992) Risk of symptomatic gallstones in women with severe obesity. Am J Clin Nutr 55:652–658

    CAS  PubMed  Google Scholar 

  12. AI-Jiffry BO, Shaffer EA, Saccone GT, Downey P, Kow L, Toouli J (2003) Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol 17:169–174

    Google Scholar 

  13. Kiewiet RM, Durian MF, van Leersum M, Hesp FLEM, van Vliet ACM (2006) Gallstone formation after weight loss following gastric banding in morbidly obese Dutch patients. Obes Surg 16:592–596

    Article  PubMed  Google Scholar 

  14. O’Brien PE, Dixon JB (2003) A rational approach to cholelithiasis in bariatric surgery. Arch Surg 138:908–912

    Article  PubMed  Google Scholar 

  15. Rubino F, Gagner M, Gentileschi P, Kini S, Fukuyama S, Feng J, Diamond E (2004) The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 240:236–242

    Article  PubMed  Google Scholar 

  16. Kellum JM, Kuemmerle JF, O’Dorisio TM, Rayford P, Martin D, Engle K, Wolf L, Sugerman HJ (1990) Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty. Ann Surg 211:763–771

    Article  CAS  PubMed  Google Scholar 

  17. Amaral JF, Thompson WR (1985) Gallbladder disease in the morbidly obese. Am J Surg 149:551–557

    Article  CAS  PubMed  Google Scholar 

  18. Shiffman ML, Sugerman HJ, Kellum JH, Brewer WH, Moore EW (1993) Gallstones in patients with morbid obesity: relationship to body weight, weight loss, and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord 17:153–158

    CAS  PubMed  Google Scholar 

  19. Miller K, Hell E, Lang B, Lengauer E (2003) Gallstone formation prophylaxis after gastric restrictive procedured for weight loss: a randomized double-blind placebo-controlled trial. Ann Surg 238:697–702

    Article  PubMed  Google Scholar 

  20. Scott DJ, Villegas L, Sims TL (2003) Intraoperative ultrasound and prophylactic ursodiol for gallstone prevention following laparoscopic gastric bypass. Surg Endosc 17:1796–1802

    Article  CAS  PubMed  Google Scholar 

  21. Ammori BJ, Vezakis A, Davides D, Martin IG, Larvin M, McMahon MJ (2001) laparoscopic cholecystectomy in morbidly obese patients. Surg Endosc 15:1136–1139

    Google Scholar 

  22. Fobi M, Lee H, Igwe D, Felaphy B, James E, Stanczyk M, Fobi N (2002) Prophylatic cholecystectomy with gastric bypass operation: incidence of gallbladder disease. Obes Surg 12:350–353

    Article  PubMed  Google Scholar 

  23. Fakhry SM, Herbst CA, Buckwalter JA (1987) Cholecystectomy in morbidly obese patients. Am Surg 53:26–28

    CAS  PubMed  Google Scholar 

  24. Jones KB Jr (1995) Simultaneous cholecystectomy: to be or not to be. Obes Surg 5:52–54

    Article  PubMed  Google Scholar 

  25. Erlinger S (2000) Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol 12:1347–1352

    Article  CAS  PubMed  Google Scholar 

  26. Yang H, Peterson GM, Roth MP, Schoenfield LJ, Marks JW (1992) Risk factors for gallstones formation during rapid loss of weight. Dig Dis Sci 37:912–918

    Article  CAS  PubMed  Google Scholar 

  27. Samuel I, Mason EE, Renquist KE, Huang YH, Zimmerman MB, Jamal M (2006) Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry. Am J Surg 192:657–662

    Article  PubMed  Google Scholar 

  28. Mark SS, John JC, Francis HS, Marleen MM, Barbara S, William T, Gary SD (1988) Ultrasound evaluation of cholelithiasis in the morbidly obese. Abdom Imaging 13:345–346

    Google Scholar 

  29. Oria HE (1998) Pitfalls in the diagnosis of gallbladder disease in clinically severe obesity. Obes Surg 8:444–451

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Raul J. Rosenthal.

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Li, V.K.M., Pulido, N., Martinez-Suartez, P. et al. Symptomatic gallstones after sleeve gastrectomy. Surg Endosc 23, 2488–2492 (2009). https://doi.org/10.1007/s00464-009-0422-6

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  • DOI: https://doi.org/10.1007/s00464-009-0422-6

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