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A randomized controlled study evaluating the effects of the temperature of insufflated CO2 on core body temperature and blood gases (an experimental study)

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Abstract

Background

Heated carbon dioxide (CO2) was used for pneumoperitoneum (Pp) to prevent hypothermia. This study aimed to investigate the relationship between the temperature of the insufflated CO2 and blood gases together with the core body temperature (CBT).

Methods

A prospective controlled study was performed with 24 pigs weighing approximately 20 kg randomized into four groups of 6 pigs each. A pneumoperitoneum at 12 mmHg of pressure was applied for 60 min with the pig under general anesthesia. The CO2 temperature was 22°C in group 1, 37°C in group 2, and 7°C in group 3. In the “sham” group, pneumoperitoneum was not applied. Arterial blood pH and partial pressure of CO2 (PaCO2) were analyzed before insufflation, every 15 min during the pneumoperitoneum, and 15 min after the desufflation. The CBT was recorded before the insufflation, every 20 min during pneumoperitoneum, and 20 min after the desufflation. Blood gas analyses and CBT records for the “sham” group were performed at the same intervals.

Results

Arterial blood pH gradually decreased during pneumoperitoneum. At the 60th minute of pneumoperitoneum, a minimum decrease in arterial blood pH (0.04; p = 0.027) and a minimum increase in PaCO2 (3.67; p = 0.027) were recorded in group 3, whereas a maximum decrease in arterial blood pH (0.18; p = 0.027) and a maximum increase in PaCO2 (17.17; p = 0.027) were recorded in group 2. There was a significant negative correlation between PaCO2 and arterial blood pH in all the groups (r = –0.993; p < 0.01). The mean values of CBT decreases were statistically significant in all the groups: group 1 (p = 0.023), group 2 (p = 0.026), group 3 (p = 0.026), and “sham” group (p = 0.024).

Conclusions

The changes in PaCO2 were directly proportional and the changes in pH contrarily proportional to the temperature of the insufflated CO2. Significant differences in CBT decreases were found between the groups receiving heated gas and room temperature gas and the groups receiving heated gas and gas below room temperature.

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Acknowledgments

The authors thank Dr. Tacettin İnandı, Dr.Cengaver Tamer, Dr Cahit Özer, and statistician Nazmiye Kurşun for their help in performing the statistical analysis of the obtained data. This research was supported in part by Çukurova Teknik, Adana, Turkey, which provided the blood gas analysator, and by Pusula Medical, Adana, Turkey, which provided the CO2 insufflator.

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Authors and Affiliations

  1. Department of General Surgery, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    E. Bashirov

  2. Central Laboratory, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    S. Cetiner

  3. Department of Biophysics, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    M. Emre

  4. Department of Cardiology, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    T. Seydaliyeva

  5. Department of Anaesthesiology, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    V. Alic & M. Ozalevli

  6. Medical Scientific Experimental Research Center, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    K. Daglioglu

  7. Department of Cardiology, Mustafa Kemal University School of Medicine, Bagriyanik mah., 31100, Antakya, Hatay, Turkey

    M. San

  8. Department of Cardiovascular Surgery, Cukurova University School of Medicine, Adana, Turkey

    M. S. Topcuoglu

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  1. E. Bashirov
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Correspondence to E. Bashirov.

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Bashirov, E., Cetiner, S., Emre, M. et al. A randomized controlled study evaluating the effects of the temperature of insufflated CO2 on core body temperature and blood gases (an experimental study). Surg Endosc 21, 1820–1825 (2007). https://doi.org/10.1007/s00464-007-9295-8

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  • DOI: https://doi.org/10.1007/s00464-007-9295-8

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