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Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model

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Abstract

Background

The use of prosthetic materials for the repair of paraesophageal hiatal hernia (PEH) may lead to esophageal stricture and perforation. High recurrence rates after primary repair have led surgeons to explore other options, including various bioprostheses. However, the long-term effects of these newer materials when placed at the esophageal hiatus are unknown. This study assessed the anatomic and histologic characteristics 1 year after PEH repair using a U-shaped configuration of commercially available small intestinal submucosa (SIS) mesh in a canine model.

Methods

Six dogs underwent laparoscopic PEH repair with SIS mesh 4 weeks after thoracoscopic creation of PEH. When the six dogs were sacrificed 12 months later, endoscopy and barium x-ray were performed, and biopsies of the esophagus and crura were obtained.

Results

The mean weight of the dogs 1 year after surgery was identical to their entry weight. No dog had gross dysphagia, evidence of esophageal stricture, or reherniation. At sacrifice, the biomaterial was not identifiable grossly. Biopsies of the hiatal region showed fibrosis as well as muscle fiber proliferation and regeneration. No dog had erosion of the mesh into the esophagus.

Conclusions

This reproducible canine model of PEH formation and repair did not result in erosion of SIS mesh into the esophagus or in stricture formation. Native muscle ingrowth was noted 1 year after placement of the biomaterial. According to the findings, SIS may provide a scaffold for ingrowth of crural muscle and a durable repair of PEH over the long term.

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Acknowledgments

The authors received an educational grant from Cook Biotech Inc. and support from Washington University Institute for Minimally Invasive Surgery (WUIMIS).

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Authors and Affiliations

  1. Department of Surgery and Institute for Minimally Invasive Surgery, Washington University School of Medicine, St. Louis, MO, USA

    K. M. Desai, S. Diaz, I. G. Dorward, E. R. Winslow, M. C. La Regina & V. Halpin

  2. Department of Surgery, Northwestern University, Chicago, IL, USA

    N. J. Soper

Authors
  1. K. M. Desai
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  2. S. Diaz
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  3. I. G. Dorward
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  4. E. R. Winslow
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  5. M. C. La Regina
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  6. V. Halpin
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  7. N. J. Soper
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Corresponding author

Correspondence to N. J. Soper.

Additional information

Presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), Denver, Colorado, 3 April 2004

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Desai, K.M., Diaz, S., Dorward, I.G. et al. Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model. Surg Endosc 20, 1693–1697 (2006). https://doi.org/10.1007/s00464-006-0680-5

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  • DOI: https://doi.org/10.1007/s00464-006-0680-5

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