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A poor response to proton pump inhibition is not a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease

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Abstract

Background

We aimed to determine if a poor response to proton pump inhibitors (PPIs) can predict a poor outcome following laparoscopic antireflux surgery (LARS) in our surgically treated population.

Methods

A total of 324 patients undergoing LARS were included in this study. Following standardized assessment, patients recorded the efficacy of their medication on visual analogue scales. Pre- and postoperative symptom scores were recorded, with outcomes measured by modified Visick scores.

Results

There were 233 good responders (>50% relief) and 91 poor responders (<49% relief). Both groups demonstrated a significant decline in postoperative symptom scores. Ninety-four percent of good responders had an excellent or good outcome, compared to 87% of poor responders. Twenty-seven patients reported a fair or poor outcome, despite improved postoperative symptom scores. Fifteen of these patients reported continuing heartburn; five had positive pH tests.

Conclusion

Our results do not support the assumption that a poor response to PPIs equates to a poor outcome after LARS.

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Authors and Affiliations

  1. Department of Laparoscopic and Upper GI Surgery, Royal Berkshire Hospital, London Road, Reading RG1 5AN, England, UK

    P. M. Wilkerson, M. I. Booth & T. C. B. Dehn

  2. Department of GI Physiology, Royal Berkshire Hospital, London Road, Reading RG1 5AN, England, UK

    J. Stratford, L. Jones & J. Sohanpal

Authors
  1. P. M. Wilkerson
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  2. J. Stratford
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  3. L. Jones
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  4. J. Sohanpal
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  5. M. I. Booth
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  6. T. C. B. Dehn
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Corresponding author

Correspondence to P. M. Wilkerson.

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Wilkerson, P., Stratford, J., Jones, L. et al. A poor response to proton pump inhibition is not a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease. Surg Endosc 19, 1272–1277 (2005). https://doi.org/10.1007/s00464-004-2238-8

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  • DOI: https://doi.org/10.1007/s00464-004-2238-8

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