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The implication of topology for protein structure and aggregation

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Zeitschrift für Physik D Atoms,Molecules and Clusters

Abstract

For proteins, it is discussed which intrinsic dynamical modes can be present when all static forces are screened. Excitations involving a wringing of the polypeptide chain around its path exists. It is suggested that the existence of such wringons is the underlying cause for the uniqueness of protein folding, and that they may be determinant for aggregation.

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References

  1. C. B. Anfinsen and H. A. Scheraga, Adv. Prot. Chem. 29, 205–300, 1975

    Article  Google Scholar 

  2. P. G. Wolynes, Spin glass ideas in the protein folding problem, in Spin glasses and biology, D. L. Stein (ed.), World Scientific Press, New York 1990

    Google Scholar 

  3. Dill K.A., Bromberg S., Yue K., Fiebig K.M., Yee D.P., Thomas P.D. and Chan H.S., Protein Science 4, 561 (1995)

    Article  Google Scholar 

  4. de Gennes, P.G., Scaling Concept in Polymer Physics, Cornell University Press, Ithaca (1979)

    Google Scholar 

  5. Bohr, J., Bohr, H., and Brunak, S., in Protein Folds: A Distance-Based Approach; Eds. H. Bohr & S. Brunak, CRC Press, New York, (1995)

  6. Bohr, J., Bohr, H., and Brunak, S., Europhysics News 27, 50 (1996)

    Article  ADS  Google Scholar 

  7. White J., American J. of Math. 91, 693 (1969)

    Article  MathSciNet  Google Scholar 

  8. Kauffman, L.H., Knots and Physics, World Scientific, Singapore (1991)

    Book  MATH  Google Scholar 

  9. Stoker, J.J., Differential Geometry, John Wiley & Sons, New York (1989)

    MATH  Google Scholar 

  10. Fuller, F.B., Proc. Natl. Acad. Sci. USA 68, 815 (1971)

    Article  ADS  Google Scholar 

  11. Crick, F.H., Proc. Natl. Acad. Sci. USA 73, 2639 (1976)

    Article  ADS  MathSciNet  Google Scholar 

  12. Fuller, F.B., Proc. Natl. Acad. Sci. USA 75, 3557 (1978)

    Article  ADS  Google Scholar 

  13. Pohl, W.F., Math. Intelligence 3, 20 (1980)

    Article  Google Scholar 

  14. Levitt, M., J. Mol. Biol. 170, 723 (1983)

    Article  Google Scholar 

  15. De Santis, P., Morosetti, S. and Palleschi A., Biopolymers 22, 37 (1983)

    Article  Google Scholar 

  16. Chiavarini, S., De Santis, P., Morosetti, S. and Palleschi A., Biopolymers 23, 1547 (1983)

    Article  Google Scholar 

  17. Wu, C.Y., Chen, S.T., Chiou, S.H., Wang, K.T. J. Protein Chem. 11, 45 (1992)

    Article  Google Scholar 

  18. Creighton T.E., Proteins, Structure and Molecular Properties, New York, Freeman (1993)

    Google Scholar 

  19. Parak, F., Knapp, E.W. and Kucheida, D., J. Mol. Biol. 161, 177 (1982)

    Article  Google Scholar 

  20. Berman, A.L., Kolker, E. and Trifonov, E.N., Proc. Natl. Acad. Sci. USA 91, 4044 (1994)

    Article  ADS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physics, The Technical University of Denmark, Building 307, DK-2800, Lyngby, Denmark

    Jakob Bohr

  2. Center for Biological Sequence Analysis, The Technical University of Denmark, Building 206, DK-2800, Lyngby, Denmark

    Henrik G. Bohr

Authors
  1. Jakob Bohr
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  2. Henrik G. Bohr
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Bohr, J., Bohr, H.G. The implication of topology for protein structure and aggregation. Z Phys D - Atoms, Molecules and Clusters 40, 186–189 (1997). https://doi.org/10.1007/s004600050190

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  • DOI: https://doi.org/10.1007/s004600050190

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