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Six-Year Follow-Up of Dysphagia in Patients with Parkinson’s Disease

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Abstract

The current study sought to examine longitudinal changes of dysphagia in Parkinson’s disease, identify predictors of dysphagia aggravation and elucidate the influence of dysphagia on other symptoms in Parkinson’s disease patients. Forty-eight patients with Parkinson’s disease were enrolled. All patients underwent videofluoroscopic study of swallowing evaluation and a battery of neuropsychological assessments at baseline in 2014 and at follow-up in 2020. We used t-tests or Wilcoxon tests for comparative analysis between patients with/without dysphagia and comparative analysis of longitudinal data. We used Spearman’s correlation analysis to examine predictors of dysphagia aggravation, and the Wilcoxon test to compare neuropsychological aggravation between patients with/without dysphagia at baseline. Swallowing function, cognitive function, depression, anxiety, and quality of life were aggravated at follow-up. Dysphagia prevalence increased from 27.08 at baseline to 39.58% at follow-up. Spearman’s correlation results showed that dysphagia was more likely to become aggravated in male patients compared with female patients (P = 0.0049). Cognitive impairment at baseline was significantly related to dysphagia aggravation (P = 0.042). Patients with dysphagia at baseline exhibited a significantly greater increase in anxiety scores than patients without dysphagia at baseline (P = 0.021). The results revealed that male sex and cognitive impairment predicted worsening dysphagia in Parkinson’s disease patients, and suggested that dysphagia may have a negative impact on anxiety in Parkinson’s disease patients. The results highlight the importance of swallowing function screening and necessary instrumental checks, such as videofluoroscopic study of swallowing, in Parkinson’s disease patients.

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Acknowledgements

We sincerely thank the patients and caregivers who participated in our study. We also acknowledge the support of the Science Technology Department of Zhejiang Province (2019C03017).

Funding

This study was supported by the Science Technology Department of Zhejiang Province (2019C03017).

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Authors and Affiliations

  1. Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China

    Ping Wang BD, Bo Wang, Xinhui Chen, Sheng Wu, Shuqi Chen, Peng Liu & Wei Luo

  2. Department of Rehabilitation, Zhejiang University School of Medicine Second Affiliated Hospital, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China

    Ping Wang BD, Bing Xiong, Fangyao Xie & Yinshan Tang

  3. Department of Neurology, Haining Chinese Medical Hospital, 177 Changdai Road, Haining, 314400, Zhejiang, China

    Xueping Ding MD

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  1. Ping Wang BD
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Correspondence to Wei Luo.

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Wang, P., Wang, B., Chen, X. et al. Six-Year Follow-Up of Dysphagia in Patients with Parkinson’s Disease. Dysphagia 37, 1271–1278 (2022). https://doi.org/10.1007/s00455-021-10387-0

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