Abstract
In this paper a simple design procedure is used to enhance the performance of a biotechnical cultivation process. A model supported approach is proposed. It starts with a simple classical process model obtained from literature data, which is used to design the first experiment. Then, the main procedure is an iteration of (i) improving the model making use of the deviations between the experimental data and the data predicted by the model, (ii) of designing the next experiment by determining the optimal control profiles from the current model, and (iii) of executing that designed experiment. Important for the success of the procedure is that the model development is oriented at the process performance. The procedure is demonstrated at the simple practical example of a laboratory-scale fed-batch cultivation of Escherichia coli.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 15 April 1997
Rights and permissions
About this article
Cite this article
Galvanauskas, V., Simutis, R., Volk, N. et al. Model based design of a biochemical cultivation process. Bioprocess Engineering 18, 227–234 (1998). https://doi.org/10.1007/s004490050435
Issue Date:
DOI: https://doi.org/10.1007/s004490050435